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Antimalarial artesunate protects sepsis model mice against heat-killed Escherichia coli challenge by decreasing TLR4, TLR9 mRNA expressions and transcription factor NF-kappa B activation.
Li B, Zhang R, Li J, Zhang L, Ding G, Luo P, He S, Dong Y, Jiang W, Lu Y, Cao H, Zheng J, Zhou H. Li B, et al. Among authors: jiang w. Int Immunopharmacol. 2008 Mar;8(3):379-89. doi: 10.1016/j.intimp.2007.10.024. Epub 2007 Dec 7. Int Immunopharmacol. 2008. PMID: 18279792
Artesunate in combination with oxacillin protect sepsis model mice challenged with lethal live methicillin-resistant Staphylococcus aureus (MRSA) via its inhibition on proinflammatory cytokines release and enhancement on antibacterial activity of oxacillin.
Jiang W, Li B, Zheng X, Liu X, Cen Y, Li J, Pan X, Cao H, Zheng J, Zhou H. Jiang W, et al. Int Immunopharmacol. 2011 Aug;11(8):1065-73. doi: 10.1016/j.intimp.2011.02.028. Epub 2011 Mar 21. Int Immunopharmacol. 2011. PMID: 21396483
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