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Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.
Gemma S, Giovani S, Brindisi M, Tripaldi P, Brogi S, Savini L, Fiorini I, Novellino E, Butini S, Campiani G, Penzo M, Blackman MJ. Gemma S, et al. Among authors: blackman mj. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5317-21. doi: 10.1016/j.bmcl.2012.06.023. Epub 2012 Jun 23. Bioorg Med Chem Lett. 2012. PMID: 22796182
Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.
Withers-Martinez C, Suarez C, Fulle S, Kher S, Penzo M, Ebejer JP, Koussis K, Hackett F, Jirgensons A, Finn P, Blackman MJ. Withers-Martinez C, et al. Among authors: blackman mj. Int J Parasitol. 2012 May 15;42(6):597-612. doi: 10.1016/j.ijpara.2012.04.005. Epub 2012 Apr 27. Int J Parasitol. 2012. PMID: 22543039 Free PMC article.
Rational design of the first difluorostatone-based PfSUB1 inhibitors.
Giovani S, Penzo M, Brogi S, Brindisi M, Gemma S, Novellino E, Savini L, Blackman MJ, Campiani G, Butini S. Giovani S, et al. Among authors: blackman mj. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3582-6. doi: 10.1016/j.bmcl.2014.05.044. Epub 2014 May 23. Bioorg Med Chem Lett. 2014. PMID: 24909083
Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.
McConville M, Fernández J, Angulo-Barturen Í, Bahamontes-Rosa N, Ballell-Pages L, Castañeda P, de Cózar C, Crespo B, Guijarro L, Jiménez-Díaz MB, Martínez-Martínez MS, de Mercado J, Santos-Villarejo Á, Sanz LM, Frigerio M, Washbourn G, Ward SA, Nixon GL, Biagini GA, Berry NG, Blackman MJ, Calderón F, O'Neill PM. McConville M, et al. Among authors: blackman mj. J Med Chem. 2015 Aug 27;58(16):6448-55. doi: 10.1021/acs.jmedchem.5b00434. Epub 2015 Aug 17. J Med Chem. 2015. PMID: 26222445
177 results