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ALDH2 mediates 5-nitrofuran activity in multiple species.
Zhou L, Ishizaki H, Spitzer M, Taylor KL, Temperley ND, Johnson SL, Brear P, Gautier P, Zeng Z, Mitchell A, Narayan V, McNeil EM, Melton DW, Smith TK, Tyers M, Westwood NJ, Patton EE. Zhou L, et al. Among authors: brear p. Chem Biol. 2012 Jul 27;19(7):883-92. doi: 10.1016/j.chembiol.2012.05.017. Chem Biol. 2012. PMID: 22840776 Free PMC article.
ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species.
Zhou L, Ishizaki H, Spitzer M, Taylor KL, Temperley ND, Johnson SL, Brear P, Gautier P, Zeng Z, Mitchell A, Narayan V, McNeil EM, Melton DW, Smith TK, Tyers M, Westwood NJ, Patton EE. Zhou L, et al. Among authors: brear p. Cell Chem Biol. 2020 Nov 19;27(11):1452. doi: 10.1016/j.chembiol.2020.10.011. Cell Chem Biol. 2020. PMID: 33217312 Free PMC article. No abstract available.
Proposed Allosteric Inhibitors Bind to the ATP Site of CK2α.
Brear P, Ball D, Stott K, D'Arcy S, Hyvönen M. Brear P, et al. J Med Chem. 2020 Nov 12;63(21):12786-12798. doi: 10.1021/acs.jmedchem.0c01173. Epub 2020 Oct 29. J Med Chem. 2020. PMID: 33119282 Free PMC article.
Specific inhibition of CK2α from an anchor outside the active site.
Brear P, De Fusco C, Hadje Georgiou K, Francis-Newton NJ, Stubbs CJ, Sore HF, Venkitaraman AR, Abell C, Spring DR, Hyvönen M. Brear P, et al. Chem Sci. 2016 Nov 1;7(11):6839-6845. doi: 10.1039/c6sc02335e. Epub 2016 Jul 12. Chem Sci. 2016. PMID: 28451126 Free PMC article.
38 results