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Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia.
Need AC, McEvoy JP, Gennarelli M, Heinzen EL, Ge D, Maia JM, Shianna KV, He M, Cirulli ET, Gumbs CE, Zhao Q, Campbell CR, Hong L, Rosenquist P, Putkonen A, Hallikainen T, Repo-Tiihonen E, Tiihonen J, Levy DL, Meltzer HY, Goldstein DB. Need AC, et al. Among authors: hong l. Am J Hum Genet. 2012 Aug 10;91(2):303-12. doi: 10.1016/j.ajhg.2012.06.018. Epub 2012 Aug 2. Am J Hum Genet. 2012. PMID: 22863191 Free PMC article.
The characterization of twenty sequenced human genomes.
Pelak K, Shianna KV, Ge D, Maia JM, Zhu M, Smith JP, Cirulli ET, Fellay J, Dickson SP, Gumbs CE, Heinzen EL, Need AC, Ruzzo EK, Singh A, Campbell CR, Hong LK, Lornsen KA, McKenzie AM, Sobreira NL, Hoover-Fong JE, Milner JD, Ottman R, Haynes BF, Goedert JJ, Goldstein DB. Pelak K, et al. Among authors: hong lk. PLoS Genet. 2010 Sep 9;6(9):e1001111. doi: 10.1371/journal.pgen.1001111. PLoS Genet. 2010. PMID: 20838461 Free PMC article.
Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy.
Heinzen EL, Depondt C, Cavalleri GL, Ruzzo EK, Walley NM, Need AC, Ge D, He M, Cirulli ET, Zhao Q, Cronin KD, Gumbs CE, Campbell CR, Hong LK, Maia JM, Shianna KV, McCormack M, Radtke RA, O'Conner GD, Mikati MA, Gallentine WB, Husain AM, Sinha SR, Chinthapalli K, Puranam RS, McNamara JO, Ottman R, Sisodiya SM, Delanty N, Goldstein DB. Heinzen EL, et al. Among authors: hong lk. Am J Hum Genet. 2012 Aug 10;91(2):293-302. doi: 10.1016/j.ajhg.2012.06.016. Epub 2012 Aug 2. Am J Hum Genet. 2012. PMID: 22863189 Free PMC article.
IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C.
Urban TJ, Thompson AJ, Bradrick SS, Fellay J, Schuppan D, Cronin KD, Hong L, McKenzie A, Patel K, Shianna KV, McHutchison JG, Goldstein DB, Afdhal N. Urban TJ, et al. Among authors: hong l. Hepatology. 2010 Dec;52(6):1888-96. doi: 10.1002/hep.23912. Epub 2010 Oct 7. Hepatology. 2010. PMID: 20931559 Free PMC article.
Pre-established Chromatin Interactions Mediate the Genomic Response to Glucocorticoids.
D'Ippolito AM, McDowell IC, Barrera A, Hong LK, Leichter SM, Bartelt LC, Vockley CM, Majoros WH, Safi A, Song L, Gersbach CA, Crawford GE, Reddy TE. D'Ippolito AM, et al. Among authors: hong lk. Cell Syst. 2018 Aug 22;7(2):146-160.e7. doi: 10.1016/j.cels.2018.06.007. Epub 2018 Jul 18. Cell Syst. 2018. PMID: 30031775 Free article.
Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations in vitro and in vivo.
Ye T, Alamgir A, Robertus CM, Colina D, Monticello C, Donahue TC, Hong L, Vincoff S, Goel S, Fekkes P, Camargo LM, Lam K, Heyes J, Putnam D, Alabi CA, Chatterjee P, DeLisa MP. Ye T, et al. Among authors: hong l. bioRxiv [Preprint]. 2024 Nov 11:2024.11.10.622803. doi: 10.1101/2024.11.10.622803. bioRxiv. 2024. PMID: 39605463 Free PMC article. Preprint.
A general temperature-guided language model to design proteins of enhanced stability and activity.
Jiang F, Li M, Dong J, Yu Y, Sun X, Wu B, Huang J, Kang L, Pei Y, Zhang L, Wang S, Xu W, Xin J, Ouyang W, Fan G, Zheng L, Tan Y, Hu Z, Xiong Y, Feng Y, Yang G, Liu Q, Song J, Liu J, Hong L, Tan P. Jiang F, et al. Among authors: hong l. Sci Adv. 2024 Nov 29;10(48):eadr2641. doi: 10.1126/sciadv.adr2641. Epub 2024 Nov 27. Sci Adv. 2024. PMID: 39602544 Free PMC article.
3,832 results