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Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia.
Need AC, McEvoy JP, Gennarelli M, Heinzen EL, Ge D, Maia JM, Shianna KV, He M, Cirulli ET, Gumbs CE, Zhao Q, Campbell CR, Hong L, Rosenquist P, Putkonen A, Hallikainen T, Repo-Tiihonen E, Tiihonen J, Levy DL, Meltzer HY, Goldstein DB. Need AC, et al. Among authors: putkonen a. Am J Hum Genet. 2012 Aug 10;91(2):303-12. doi: 10.1016/j.ajhg.2012.06.018. Epub 2012 Aug 2. Am J Hum Genet. 2012. PMID: 22863191 Free PMC article.
Exome sequence analysis of Finnish patients with clozapine-induced agranulocytosis.
Tiwari AK, Need AC, Lohoff FW, Zai CC, Chowdhury NI, Müller DJ, Putkonen A, Repo-Tiihonen E, Hallikainen T, Yağcıoğlu AE, Tiihonen J, Kennedy JL, Meltzer HY. Tiwari AK, et al. Among authors: putkonen a. Mol Psychiatry. 2014 Apr;19(4):403-5. doi: 10.1038/mp.2013.74. Epub 2013 Jun 11. Mol Psychiatry. 2014. PMID: 23752246 No abstract available.
Suicidal behavior in patients with schizophrenia is related to COMT polymorphism.
Nolan KA, Volavka J, Czobor P, Cseh A, Lachman H, Saito T, Tiihonen J, Putkonen A, Hallikainen T, Kotilainen I, Räsänen P, Isohanni M, Järvelin MR, Karvonen MK. Nolan KA, et al. Among authors: putkonen a. Psychiatr Genet. 2000 Sep;10(3):117-24. doi: 10.1097/00041444-200010030-00003. Psychiatr Genet. 2000. PMID: 11204347
[Lamotrigine in clozapine treatment-resistant schizophrenia].
Tiihonen J, Hallikainen T, Ryynänen OP, Repo-Tiihonen E, Kotilainen I, Eronen M, Toivonen P, Wahlbeck K, Putkonen A. Tiihonen J, et al. Among authors: putkonen a. Duodecim. 2004;120(1):85-6. Duodecim. 2004. PMID: 14976813 Clinical Trial. Finnish. No abstract available.
[Restrictions during psychiatric hospitalization].
Repo-Tiihonen E, Putkonen A, Tuppurainen H. Repo-Tiihonen E, et al. Among authors: putkonen a. Duodecim. 2012;128(22):2336-43. Duodecim. 2012. PMID: 23342480 Finnish.
HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry.
Konte B, Walters JTR, Rujescu D, Legge SE, Pardiñas AF, Cohen D, Pirmohamed M, Tiihonen J, Hartmann AM, Bogers JP, van der Weide J, van der Weide K, Putkonen A, Repo-Tiihonen E, Hallikainen T, Silva E, Ingimarsson O, Sigurdsson E, Kennedy JL, Sullivan PF, Rietschel M, Breen G, Stefansson H, Stefansson K, Collier DA, O'Donovan MC, Giegling I. Konte B, et al. Among authors: putkonen a. Transl Psychiatry. 2021 Apr 12;11(1):214. doi: 10.1038/s41398-021-01322-w. Transl Psychiatry. 2021. PMID: 33846298 Free PMC article.
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