Hayler JF - Search Results

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Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway.

Bruce I, Akhlaq M, Bloomfield GC, Budd E, Cox B, Cuenoud B, Finan P, Gedeck P, Hatto J, Hayler JF, Head D, Keller T, Kirman L, Leblanc C, Le Grand D, McCarthy C, O'Connor D, Owen C, Oza MS, Pilgrim G, Press NE, Sviridenko L, Whitehead L. Bruce I, et al. Among authors: hayler jf. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5445-50. doi: 10.1016/j.bmcl.2012.07.042. Epub 2012 Jul 17. Bioorg Med Chem Lett. 2012. PMID: 22863202

Studies towards the identification of potent, selective and bioavailable thrombin inhibitors.

Ambler J, Baker E, Bentley D, Brown L, Butler K, Butler P, Farr D, Dunnet K, Le Grand D, Hayler J, Janus D, Jones D, Menear K, Mercer M, Smith G, Talbot M, Tweed M. Ambler J, et al. Bioorg Med Chem Lett. 1999 Mar 8;9(5):737-42. doi: 10.1016/s0960-894x(99)00061-x. Bioorg Med Chem Lett. 1999. PMID: 10201839

The design and synthesis of thrombin inhibitors: the introduction of in vivo efficacy and oral bioavailability into benzthiazolylalanine inhibitors.

Hayler J, Kane PD, LeGrand D, Lugrin F, Menear K, Price R, Allen M, Cockcroft X, Ambler J, Butler K, Dunnet K, Mitchelson A, Talbot M, Tweed M, Wills N. Hayler J, et al. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1567-70. doi: 10.1016/s0960-894x(00)00283-3. Bioorg Med Chem Lett. 2000. PMID: 10915052

Optimisation of the P2 pharmacophore in a series of thrombin inhibitors: ion-dipole interactions with lysine 60G.

Ambler J, Brown L, Cockcroft XL, Grütter M, Hayler J, Janus D, Jones D, Kane P, Menear K, Priestle J, Smith G, Talbot M, Walker CV, Wathey B. Ambler J, et al. Bioorg Med Chem Lett. 1999 May 3;9(9):1317-22. doi: 10.1016/s0960-894x(99)00172-9. Bioorg Med Chem Lett. 1999. PMID: 10340621

Design and synthesis of thrombin inhibitors: analogues of MD-805 with reduced stereogenicity and improved potency.

Brundish D, Bull A, Donovan V, Fullerton JD, Garman SM, Hayler JF, Janus D, Kane PD, McDonnell M, Smith GP, Wakeford R, Walker CV, Howarth G, Hoyle W, Allen MC, Ambler J, Butler K, Talbot MD. Brundish D, et al. Among authors: hayler jf. J Med Chem. 1999 Nov 4;42(22):4584-603. doi: 10.1021/jm9811209. J Med Chem. 1999. PMID: 10579821

Conjugate addition of 2- and 4-pyridylcuprates: an expeditious asymmetric synthesis of natural (-)-evoninic acid.

Spivey AC, Shukla L, Hayler JF. Spivey AC, et al. Among authors: hayler jf. Org Lett. 2007 Mar 1;9(5):891-4. doi: 10.1021/ol070011y. Epub 2007 Feb 9. Org Lett. 2007. PMID: 17288430

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