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Page 1
Assessment of metabolic stability using the rainbow trout (Oncorhynchus mykiss) liver S9 fraction.
Johanning K, Hancock G, Escher B, Adekola A, Bernhard MJ, Cowan-Ellsberry C, Domoradzki J, Dyer S, Eickhoff C, Embry M, Erhardt S, Fitzsimmons P, Halder M, Hill J, Holden D, Johnson R, Rutishauser S, Segner H, Schultz I, Nichols J. Johanning K, et al. Among authors: domoradzki j. Curr Protoc Toxicol. 2012 Aug;Chapter 14:Unit 14.10.1-28. doi: 10.1002/0471140856.tx1410s53. Curr Protoc Toxicol. 2012. PMID: 22896006
Predicting nonlinear relationships between external and internal concentrations with physiologically based pharmacokinetic modeling.
Hoer D, Barton HA, Paini A, Bartels M, Ingle B, Domoradzki J, Fisher J, Embry M, Villanueva P, Miller D, Nguyen J, Zhang Q, Edwards SW, Tan YM. Hoer D, et al. Among authors: domoradzki j. Toxicol Appl Pharmacol. 2022 Apr 1;440:115922. doi: 10.1016/j.taap.2022.115922. Epub 2022 Feb 15. Toxicol Appl Pharmacol. 2022. PMID: 35176293 Free PMC article.
PBPK model reporting template for chemical risk assessment applications.
Tan YM, Chan M, Chukwudebe A, Domoradzki J, Fisher J, Hack CE, Hinderliter P, Hirasawa K, Leonard J, Lumen A, Paini A, Qian H, Ruiz P, Wambaugh J, Zhang F, Embry M. Tan YM, et al. Among authors: domoradzki j. Regul Toxicol Pharmacol. 2020 Aug;115:104691. doi: 10.1016/j.yrtph.2020.104691. Epub 2020 Jun 2. Regul Toxicol Pharmacol. 2020. PMID: 32502513 Free PMC article. Review.
Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment.
Tan YM, Barton HA, Boobis A, Brunner R, Clewell H, Cope R, Dawson J, Domoradzki J, Egeghy P, Gulati P, Ingle B, Kleinstreuer N, Lowe K, Lowit A, Mendez E, Miller D, Minucci J, Nguyen J, Paini A, Perron M, Phillips K, Qian H, Ramanarayanan T, Sewell F, Villanueva P, Wambaugh J, Embry M. Tan YM, et al. Among authors: domoradzki j. Regul Toxicol Pharmacol. 2021 Dec;127:105070. doi: 10.1016/j.yrtph.2021.105070. Epub 2021 Oct 28. Regul Toxicol Pharmacol. 2021. PMID: 34718074 Free PMC article.
Letter to the editor regarding Heringa et al. (2020) paper entitled "Use of the Kinetically-derived Maximum Dose concept in selection of top doses for toxicity studies hampers proper hazard assessment and risk management".
Terry C, Domoradzki JY, Fleming CR, Gehen SC, Mingoia RT, Murphy LA, Bartels MJ. Terry C, et al. Among authors: domoradzki jy. Regul Toxicol Pharmacol. 2020 Nov;117:104765. doi: 10.1016/j.yrtph.2020.104765. Epub 2020 Aug 31. Regul Toxicol Pharmacol. 2020. PMID: 32882312 No abstract available.
Recommendations on dose level selection for repeat dose toxicity studies.
Sewell F, Corvaro M, Andrus A, Burke J, Daston G, Delaney B, Domoradzki J, Forlini C, Green ML, Hofmann T, Jäckel S, Lee MS, Temerowski M, Whalley P, Lewis R. Sewell F, et al. Among authors: domoradzki j. Arch Toxicol. 2022 Jul;96(7):1921-1934. doi: 10.1007/s00204-022-03293-3. Epub 2022 Apr 29. Arch Toxicol. 2022. PMID: 35486138 Free PMC article. Review.
31 results