Fitzsimmons P - Search Results

1

Assessment of metabolic stability using the rainbow trout (Oncorhynchus mykiss) liver S9 fraction.

Johanning K, Hancock G, Escher B, Adekola A, Bernhard MJ, Cowan-Ellsberry C, Domoradzki J, Dyer S, Eickhoff C, Embry M, Erhardt S, Fitzsimmons P, Halder M, Hill J, Holden D, Johnson R, Rutishauser S, Segner H, Schultz I, Nichols J. Johanning K, et al. Among authors: fitzsimmons p. Curr Protoc Toxicol. 2012 Aug;Chapter 14:Unit 14.10.1-28. doi: 10.1002/0471140856.tx1410s53. Curr Protoc Toxicol. 2012. PMID: 22896006

2

Branchial elimination of superhydrophobic organic compounds by rainbow trout (Oncorhynchus mykiss).

Fitzsimmons PN, Fernandez JD, Hoffman AD, Butterworth BC, Nichols JW. Fitzsimmons PN, et al. Aquat Toxicol. 2001 Nov 1;55(1-2):23-34. doi: 10.1016/s0166-445x(01)00174-6. Aquat Toxicol. 2001. PMID: 11551619

3

A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish: II. simulation of chronic exposure scenarios.

Nichols JW, Fitzsimmons PN, Whiteman FW. Nichols JW, et al. Toxicol Sci. 2004 Feb;77(2):219-29. doi: 10.1093/toxsci/kfh032. Epub 2003 Dec 2. Toxicol Sci. 2004. PMID: 14657516

4

In vitro-in vivo extrapolation of quantitative hepatic biotransformation data for fish. I. A review of methods, and strategies for incorporating intrinsic clearance estimates into chemical kinetic models.

Nichols JW, Schultz IR, Fitzsimmons PN. Nichols JW, et al. Aquat Toxicol. 2006 Jun 10;78(1):74-90. doi: 10.1016/j.aquatox.2006.01.017. Epub 2006 Feb 28. Aquat Toxicol. 2006. PMID: 16513189 Review.

5

A compilation of in vitro rate and affinity values for xenobiotic biotransformation in fish, measured under physiological conditions.

Fitzsimmons PN, Lien GJ, Nichols JW. Fitzsimmons PN, et al. Comp Biochem Physiol C Toxicol Pharmacol. 2007 May;145(4):485-506. doi: 10.1016/j.cbpc.2006.12.011. Epub 2007 Jan 12. Comp Biochem Physiol C Toxicol Pharmacol. 2007. PMID: 17360241 Review.

6

In vitro-in vivo extrapolation of quantitative hepatic biotransformation data for fish. II. Modeled effects on chemical bioaccumulation.

Nichols JW, Fitzsimmons PN, Burkhard LP. Nichols JW, et al. Among authors: fitzsimmons pn. Environ Toxicol Chem. 2007 Jun;26(6):1304-19. doi: 10.1897/06-259r.1. Environ Toxicol Chem. 2007. PMID: 17571698

7

Use of online microdialysis sampling to determine the in vivo rate of phenol glucuronidation in rainbow trout.

Nichols JW, Hoffman AD, Fitzsimmons PN, Lien GJ, Jenson CT. Nichols JW, et al. Drug Metab Dispos. 2008 Jul;36(7):1406-13. doi: 10.1124/dmd.107.020123. Epub 2008 Apr 17. Drug Metab Dispos. 2008. PMID: 18420782

8

Kinetics and effects of dichloroacetic acid in rainbow trout.

Fitzsimmons PN, Hoffman AD, Lien GJ, Hammermeister DE, Nichols JW. Fitzsimmons PN, et al. Aquat Toxicol. 2009 Sep 14;94(3):186-94. doi: 10.1016/j.aquatox.2009.07.001. Epub 2009 Jul 10. Aquat Toxicol. 2009. PMID: 19656582

9

Optimization of an isolated perfused rainbow trout liver model: Clearance studies with 7-ethoxycoumarin.

Nichols JW, Hoffman AD, Fitzsimmons PN. Nichols JW, et al. Aquat Toxicol. 2009 Nov 27;95(3):182-94. doi: 10.1016/j.aquatox.2009.09.003. Epub 2009 Sep 13. Aquat Toxicol. 2009. PMID: 19837470

10

Quantification of phenol, phenyl glucuronide, and phenyl sulfate in blood of unanesthetized rainbow trout by online microdialysis sampling.

Nichols JW, Hoffman AD, Fitzsimmons PN, Lien GJ. Nichols JW, et al. Toxicol Mech Methods. 2008;18(5):405-12. doi: 10.1080/15376510701511935. Toxicol Mech Methods. 2008. PMID: 20020864

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