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A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis.
Esapa CT, Head RA, Jeyabalan J, Evans H, Hough TA, Cheeseman MT, McNally EG, Carr AJ, Thomas GP, Brown MA, Croucher PI, Brown SD, Cox RD, Thakker RV. Esapa CT, et al. Among authors: thakker rv. PLoS One. 2012;7(8):e43205. doi: 10.1371/journal.pone.0043205. Epub 2012 Aug 13. PLoS One. 2012. PMID: 22912827 Free PMC article.
Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.
Harding B, Lemos MC, Reed AA, Walls GV, Jeyabalan J, Bowl MR, Tateossian H, Sullivan N, Hough T, Fraser WD, Ansorge O, Cheeseman MT, Thakker RV. Harding B, et al. Among authors: thakker rv. Endocr Relat Cancer. 2009 Dec;16(4):1313-27. doi: 10.1677/ERC-09-0082. Epub 2009 Jul 20. Endocr Relat Cancer. 2009. PMID: 19620250 Free PMC article.
Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2.
Grigorieva IV, Mirczuk S, Gaynor KU, Nesbit MA, Grigorieva EF, Wei Q, Ali A, Fairclough RJ, Stacey JM, Stechman MJ, Mihai R, Kurek D, Fraser WD, Hough T, Condie BG, Manley N, Grosveld F, Thakker RV. Grigorieva IV, et al. Among authors: thakker rv. J Clin Invest. 2010 Jun;120(6):2144-55. doi: 10.1172/JCI42021. Epub 2010 May 17. J Clin Invest. 2010. PMID: 20484821 Free PMC article.
382 results