Bothwell IR - Search Results

1

Se-adenosyl-L-selenomethionine cofactor analogue as a reporter of protein methylation.

Bothwell IR, Islam K, Chen Y, Zheng W, Blum G, Deng H, Luo M. Bothwell IR, et al. J Am Chem Soc. 2012 Sep 12;134(36):14905-12. doi: 10.1021/ja304782r. Epub 2012 Sep 4. J Am Chem Soc. 2012. PMID: 22917021 Free PMC article.

2

Profiling protein methylation with cofactor analog containing terminal alkyne functionality.

Blum G, Bothwell IR, Islam K, Luo M. Blum G, et al. Among authors: bothwell ir. Curr Protoc Chem Biol. 2013;5(1):67-88. doi: 10.1002/9780470559277.ch120241. Curr Protoc Chem Biol. 2013. PMID: 23788324 Free PMC article.

3

Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.

Islam K, Chen Y, Wu H, Bothwell IR, Blum GJ, Zeng H, Dong A, Zheng W, Min J, Deng H, Luo M. Islam K, et al. Among authors: bothwell ir. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16778-83. doi: 10.1073/pnas.1216365110. Epub 2013 Sep 30. Proc Natl Acad Sci U S A. 2013. PMID: 24082136 Free PMC article.

4

Large-scale, protection-free synthesis of Se-adenosyl-L-selenomethionine analogues and their application as cofactor surrogates of methyltransferases.

Bothwell IR, Luo M. Bothwell IR, et al. Org Lett. 2014 Jun 6;16(11):3056-9. doi: 10.1021/ol501169y. Epub 2014 May 22. Org Lett. 2014. PMID: 24852128 Free PMC article.

5

Bioorthogonal profiling of protein methylation using azido derivative of S-adenosyl-L-methionine.

Islam K, Bothwell I, Chen Y, Sengelaub C, Wang R, Deng H, Luo M. Islam K, et al. J Am Chem Soc. 2012 Apr 4;134(13):5909-15. doi: 10.1021/ja2118333. Epub 2012 Mar 26. J Am Chem Soc. 2012. PMID: 22404544 Free PMC article.

6

Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8.

Linscott JA, Kapilashrami K, Wang Z, Senevirathne C, Bothwell IR, Blum G, Luo M. Linscott JA, et al. Among authors: bothwell ir. Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8369-E8378. doi: 10.1073/pnas.1609032114. Epub 2016 Dec 9. Proc Natl Acad Sci U S A. 2016. PMID: 27940912 Free PMC article.

7

N⁶-Allyladenosine: A New Small Molecule for RNA Labeling Identified by Mutation Assay.

Shu X, Dai Q, Wu T, Bothwell IR, Yue Y, Zhang Z, Cao J, Fei Q, Luo M, He C, Liu J. Shu X, et al. Among authors: bothwell ir. J Am Chem Soc. 2017 Dec 6;139(48):17213-17216. doi: 10.1021/jacs.7b06837. Epub 2017 Nov 15. J Am Chem Soc. 2017. PMID: 29116772 Free PMC article.

8

Expanding the structural diversity of polyketides by exploring the cofactor tolerance of an inline methyltransferase domain.

Winter JM, Chiou G, Bothwell IR, Xu W, Garg NK, Luo M, Tang Y. Winter JM, et al. Among authors: bothwell ir. Org Lett. 2013 Jul 19;15(14):3774-7. doi: 10.1021/ol401723h. Epub 2013 Jul 9. Org Lett. 2013. PMID: 23837609 Free PMC article.

9

O-Methyltransferase-Mediated Incorporation of a β-Amino Acid in Lanthipeptides.

Acedo JZ, Bothwell IR, An L, Trouth A, Frazier C, van der Donk WA. Acedo JZ, et al. Among authors: bothwell ir. J Am Chem Soc. 2019 Oct 23;141(42):16790-16801. doi: 10.1021/jacs.9b07396. Epub 2019 Oct 15. J Am Chem Soc. 2019. PMID: 31568727 Free PMC article.

10

Discovery and Characterization of a Class IV Lanthipeptide with a Nonoverlapping Ring Pattern.

Ren H, Shi C, Bothwell IR, van der Donk WA, Zhao H. Ren H, et al. Among authors: bothwell ir. ACS Chem Biol. 2020 Jun 19;15(6):1642-1649. doi: 10.1021/acschembio.0c00267. Epub 2020 May 14. ACS Chem Biol. 2020. PMID: 32356655 Free PMC article.

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