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Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis.
Castellano JM, Deane R, Gottesdiener AJ, Verghese PB, Stewart FR, West T, Paoletti AC, Kasper TR, DeMattos RB, Zlokovic BV, Holtzman DM. Castellano JM, et al. Among authors: gottesdiener aj. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15502-7. doi: 10.1073/pnas.1206446109. Epub 2012 Aug 27. Proc Natl Acad Sci U S A. 2012. PMID: 22927427 Free PMC article.
Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.
Zhao L, Gottesdiener AJ, Parmar M, Li M, Kaminsky SM, Chiuchiolo MJ, Sondhi D, Sullivan PM, Holtzman DM, Crystal RG, Paul SM. Zhao L, et al. Among authors: gottesdiener aj. Neurobiol Aging. 2016 Aug;44:159-172. doi: 10.1016/j.neurobiolaging.2016.04.020. Epub 2016 Apr 30. Neurobiol Aging. 2016. PMID: 27318144