Houghten RA - Search Results

1

Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.

Minond D, Cudic M, Bionda N, Giulianotti M, Maida L, Houghten RA, Fields GB. Minond D, et al. Among authors: houghten ra. J Biol Chem. 2012 Oct 19;287(43):36473-87. doi: 10.1074/jbc.M112.389114. Epub 2012 Aug 27. J Biol Chem. 2012. PMID: 22927435 Free PMC article.

2

Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates.

Stawikowska R, Cudic M, Giulianotti M, Houghten RA, Fields GB, Minond D. Stawikowska R, et al. Among authors: houghten ra. J Biol Chem. 2013 Aug 2;288(31):22871-9. doi: 10.1074/jbc.M113.462267. Epub 2013 Jun 18. J Biol Chem. 2013. PMID: 23779109 Free PMC article.

3

Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition.

Chavaroche A, Cudic M, Giulianotti M, Houghten RA, Fields GB, Minond D. Chavaroche A, et al. Among authors: houghten ra. Anal Biochem. 2014 Mar 15;449:68-75. doi: 10.1016/j.ab.2013.12.018. Epub 2013 Dec 19. Anal Biochem. 2014. PMID: 24361716 Free PMC article.

4

SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.

Knapinska AM, Dreymuller D, Ludwig A, Smith L, Golubkov V, Sohail A, Fridman R, Giulianotti M, LaVoi TM, Houghten RA, Fields GB, Minond D. Knapinska AM, et al. Among authors: houghten ra. J Med Chem. 2015 Aug 13;58(15):5808-24. doi: 10.1021/acs.jmedchem.5b00354. Epub 2015 Aug 4. J Med Chem. 2015. PMID: 26192023 Free PMC article.

5

A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries.

Giulianotti MA, Debevec G, Santos RG, Maida LE, Chen W, Ou L, Yu Y, Dooley CT, Houghten RA. Giulianotti MA, et al. Among authors: houghten ra. ACS Comb Sci. 2012 Sep 10;14(9):503-12. doi: 10.1021/co300060s. Epub 2012 Aug 28. ACS Comb Sci. 2012. PMID: 22913403 Free PMC article.

6

Fluorescent mu selective opioid ligands from a mixture based cyclic peptide library.

Li Y, Dooley CT, Misler JA, Debevec G, Giulianotti MA, Cazares ME, Maida L, Houghten RA. Li Y, et al. Among authors: houghten ra. ACS Comb Sci. 2012 Dec 10;14(12):673-9. doi: 10.1021/co300110t. Epub 2012 Nov 8. ACS Comb Sci. 2012. PMID: 23110623 Free PMC article.

7

The mathematics of a successful deconvolution: a quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors.

Santos RG, Appel JR, Giulianotti MA, Edwards BS, Sklar LA, Houghten RA, Pinilla C. Santos RG, et al. Among authors: houghten ra. Molecules. 2013 May 30;18(6):6408-24. doi: 10.3390/molecules18066408. Molecules. 2013. PMID: 23722730 Free PMC article.

8

Scaffold ranking and positional scanning utilized in the discovery of nAChR-selective compounds suitable for optimization studies.

Wu J, Zhang Y, Maida LE, Santos RG, Welmaker GS, LaVoi TM, Nefzi A, Yu Y, Houghten RA, Toll L, Giulianotti MA. Wu J, et al. Among authors: houghten ra. J Med Chem. 2013 Dec 27;56(24):10103-17. doi: 10.1021/jm401543h. Epub 2013 Dec 12. J Med Chem. 2013. PMID: 24274400 Free PMC article.

9

Novel pyrrolidine diketopiperazines selectively inhibit melanoma cells via induction of late-onset apoptosis.

Onwuha-Ekpete L, Tack L, Knapinska A, Smith L, Kaushik G, Lavoi T, Giulianotti M, Houghten RA, Fields GB, Minond D. Onwuha-Ekpete L, et al. Among authors: houghten ra. J Med Chem. 2014 Feb 27;57(4):1599-608. doi: 10.1021/jm4019542. Epub 2014 Feb 5. J Med Chem. 2014. PMID: 24471466 Free PMC article.

10

Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities.

Hu M, Giulianotti MA, McLaughlin JP, Shao J, Debevec G, Maida LE, Geer P, Cazares M, Misler J, Li L, Dooley C, Ganno ML, Eans SO, Mizrachi E, Santos RG, Yongye AB, Houghten RA, Yu Y. Hu M, et al. Among authors: houghten ra. Eur J Med Chem. 2015 Mar 6;92:270-81. doi: 10.1016/j.ejmech.2014.12.049. Epub 2014 Dec 29. Eur J Med Chem. 2015. PMID: 25559207

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