Loyet KM - Search Results

1

Activation of the alternative complement pathway in vitreous is controlled by genetics in age-related macular degeneration.

Loyet KM, Deforge LE, Katschke KJ Jr, Diehl L, Graham RR, Pao L, Sturgeon L, Lewin-Koh SC, Hollyfield JG, van Lookeren Campagne M. Loyet KM, et al. Invest Ophthalmol Vis Sci. 2012 Sep 25;53(10):6628-37. doi: 10.1167/iovs.12-9587. Invest Ophthalmol Vis Sci. 2012. PMID: 22930722

2

Structural and functional analysis of a C3b-specific antibody that selectively inhibits the alternative pathway of complement.

Katschke KJ Jr, Stawicki S, Yin J, Steffek M, Xi H, Sturgeon L, Hass PE, Loyet KM, Deforge L, Wu Y, van Lookeren Campagne M, Wiesmann C. Katschke KJ Jr, et al. Among authors: loyet km. J Biol Chem. 2009 Apr 17;284(16):10473-9. doi: 10.1074/jbc.M809106200. Epub 2009 Feb 5. J Biol Chem. 2009. PMID: 19196712 Free PMC article.

3

Technology comparisons for anti-therapeutic antibody and neutralizing antibody assays in the context of an anti-TNF pharmacokinetic study.

Loyet KM, Deng R, Liang WC, Wu Y, Lowman HB, DeForge LE. Loyet KM, et al. J Immunol Methods. 2009 Jun 30;345(1-2):17-28. doi: 10.1016/j.jim.2009.03.012. Epub 2009 Apr 2. J Immunol Methods. 2009. PMID: 19345224

4

Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-{alpha} antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys.

Deng R, Loyet KM, Lien S, Iyer S, DeForge LE, Theil FP, Lowman HB, Fielder PJ, Prabhu S. Deng R, et al. Among authors: loyet km. Drug Metab Dispos. 2010 Apr;38(4):600-5. doi: 10.1124/dmd.109.031310. Epub 2010 Jan 13. Drug Metab Dispos. 2010. PMID: 20071453 Clinical Trial.

5

Evaluation of heterophilic antibody blocking agents in reducing false positive interference in immunoassays for IL-17AA, IL-17FF, and IL-17AF.

DeForge LE, Loyet KM, Delarosa D, Chinn J, Zamanian F, Chuntharapai A, Lee J, Hass P, Wei N, Townsend MJ, Wang J, Wong WL. DeForge LE, et al. Among authors: loyet km. J Immunol Methods. 2010 Oct 31;362(1-2):70-81. doi: 10.1016/j.jim.2010.09.004. Epub 2010 Sep 9. J Immunol Methods. 2010. PMID: 20833179

6

Complement inhibition in cynomolgus monkeys by anti-factor d antigen-binding fragment for the treatment of an advanced form of dry age-related macular degeneration.

Loyet KM, Good J, Davancaze T, Sturgeon L, Wang X, Yang J, Le KN, Wong M, Hass PE, van Lookeren Campagne M, Haughney PC, Morimoto A, Damico-Beyer LA, DeForge LE. Loyet KM, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):527-37. doi: 10.1124/jpet.114.215921. Epub 2014 Sep 17. J Pharmacol Exp Ther. 2014. PMID: 25232192

7

A mechanistic pharmacokinetic/pharmacodynamic model of factor D inhibition in cynomolgus monkeys by lampalizumab for the treatment of geographic atrophy.

Le KN, Gibiansky L, Good J, Davancaze T, van Lookeren Campagne M, Loyet KM, Morimoto A, Jin J, Damico-Beyer LA, Hanley WD. Le KN, et al. Among authors: loyet km. J Pharmacol Exp Ther. 2015 Nov;355(2):288-96. doi: 10.1124/jpet.115.227223. J Pharmacol Exp Ther. 2015. PMID: 26359312

8

Population Pharmacokinetics and Pharmacodynamics of Lampalizumab Administered Intravitreally to Patients With Geographic Atrophy.

Le KN, Gibiansky L, van Lookeren Campagne M, Good J, Davancaze T, Loyet KM, Morimoto A, Strauss EC, Jin JY. Le KN, et al. Among authors: loyet km. CPT Pharmacometrics Syst Pharmacol. 2015 Oct;4(10):595-604. doi: 10.1002/psp4.12031. Epub 2015 Oct 8. CPT Pharmacometrics Syst Pharmacol. 2015. PMID: 26535160 Free PMC article.

9

Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye.

Tesar D, Luoma J, Wyatt EA, Shi C, Shatz W, Hass PE, Mathieu M, Yi L, Corn JE, Maass KF, Wang K, Dion MZ, Andersen N, Loyet KM, van Lookeren Campagne M, Rajagopal K, Dickmann L, Scheer JM, Kelley RF. Tesar D, et al. Among authors: loyet km. MAbs. 2017 Nov/Dec;9(8):1297-1305. doi: 10.1080/19420862.2017.1372078. Epub 2017 Aug 30. MAbs. 2017. PMID: 28854082 Free PMC article.

10

Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases.

Stefanich EG, Rae J, Sukumaran S, Lutman J, Lekkerkerker A, Ouyang W, Wang X, Lee D, Danilenko DM, Diehl L, Loyet KM, Herman A. Stefanich EG, et al. Among authors: loyet km. Biochem Pharmacol. 2018 Jun;152:224-235. doi: 10.1016/j.bcp.2018.03.031. Epub 2018 Mar 31. Biochem Pharmacol. 2018. PMID: 29608910

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