Sigurdardottir A - Search Results

1

Biophysical and computational fragment-based approaches to targeting protein-protein interactions: applications in structure-guided drug discovery.

Winter A, Higueruelo AP, Marsh M, Sigurdardottir A, Pitt WR, Blundell TL. Winter A, et al. Among authors: sigurdardottir a. Q Rev Biophys. 2012 Nov;45(4):383-426. doi: 10.1017/S0033583512000108. Epub 2012 Sep 13. Q Rev Biophys. 2012. PMID: 22971516 Review.

2

Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations.

Sampson JM, Cannon DA, Duan J, Epstein JCK, Sergeeva AP, Katsamba PS, Mannepalli SM, Bahna FA, Adihou H, Guéret SM, Gopalakrishnan R, Geschwindner S, Rees DG, Sigurdardottir A, Wilkinson T, Dodd RB, De Maria L, Mobarec JC, Shapiro L, Honig B, Buchanan A, Friesner RA, Wang L. Sampson JM, et al. Among authors: sigurdardottir a. bioRxiv [Preprint]. 2024 Apr 24:2024.04.22.590325. doi: 10.1101/2024.04.22.590325. bioRxiv. 2024. Update in: J Mol Biol. 2024 Aug 15;436(16):168640. doi: 10.1016/j.jmb.2024.168640 PMID: 38712280 Free PMC article. Updated. Preprint.

3

Text Messaging to Enhance Mindfulness-Based Smoking Cessation Treatment: Program Development Through Qualitative Research.

Spears CA, Bell SA, Scarlett CA, Anderson NK, Cottrell-Daniels C, Lotfalian S, Bandlamudi M, Grant A, Sigurdardottir A, Carter BP, Abroms LC, Wetter DW. Spears CA, et al. Among authors: sigurdardottir a. JMIR Mhealth Uhealth. 2019 Jan 7;7(1):e11246. doi: 10.2196/11246. JMIR Mhealth Uhealth. 2019. PMID: 30617043 Free PMC article.

4

Developing Antagonists for the Met-HGF/SF Protein-Protein Interaction Using a Fragment-Based Approach.

Winter A, Sigurdardottir AG, DiCara D, Valenti G, Blundell TL, Gherardi E. Winter A, et al. Among authors: sigurdardottir ag. Mol Cancer Ther. 2016 Jan;15(1):3-14. doi: 10.1158/1535-7163.MCT-15-0446. Epub 2015 Dec 28. Mol Cancer Ther. 2016. PMID: 26712116

5

Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.

Sigurdardottir AG, Winter A, Sobkowicz A, Fragai M, Chirgadze D, Ascher DB, Blundell TL, Gherardi E. Sigurdardottir AG, et al. Chem Sci. 2015 Nov 1;6(11):6147-6157. doi: 10.1039/c5sc02155c. Epub 2015 Jul 31. Chem Sci. 2015. PMID: 30090230 Free PMC article.

6

Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B.

Krzyzosiak A, Sigurdardottir A, Luh L, Carrara M, Das I, Schneider K, Bertolotti A. Krzyzosiak A, et al. Among authors: sigurdardottir a. Cell. 2018 Aug 23;174(5):1216-1228.e19. doi: 10.1016/j.cell.2018.06.030. Epub 2018 Jul 26. Cell. 2018. PMID: 30057111 Free PMC article.

7

Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors.

Carrara M, Sigurdardottir A, Bertolotti A. Carrara M, et al. Among authors: sigurdardottir a. Nat Struct Mol Biol. 2017 Sep;24(9):708-716. doi: 10.1038/nsmb.3443. Epub 2017 Jul 31. Nat Struct Mol Biol. 2017. PMID: 28759048 Free PMC article.

8

An inducible chaperone adapts proteasome assembly to stress.

Hanssum A, Zhong Z, Rousseau A, Krzyzosiak A, Sigurdardottir A, Bertolotti A. Hanssum A, et al. Among authors: sigurdardottir a. Mol Cell. 2014 Aug 21;55(4):566-77. doi: 10.1016/j.molcel.2014.06.017. Epub 2014 Jul 17. Mol Cell. 2014. PMID: 25042801 Free PMC article.

9

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.

Das I, Krzyzosiak A, Schneider K, Wrabetz L, D'Antonio M, Barry N, Sigurdardottir A, Bertolotti A. Das I, et al. Among authors: sigurdardottir a. Science. 2015 Apr 10;348(6231):239-42. doi: 10.1126/science.aaa4484. Science. 2015. PMID: 25859045 Free PMC article.

10

Robust Prediction of Relative Binding Energies for Protein-Protein Complex Mutations Using Free Energy Perturbation Calculations.

Sampson JM, Cannon DA, Duan J, Epstein JCK, Sergeeva AP, Katsamba PS, Mannepalli SM, Bahna FA, Adihou H, Guéret SM, Gopalakrishnan R, Geschwindner S, Rees DG, Sigurdardottir A, Wilkinson T, Dodd RB, De Maria L, Mobarec JC, Shapiro L, Honig B, Buchanan A, Friesner RA, Wang L. Sampson JM, et al. Among authors: sigurdardottir a. J Mol Biol. 2024 Aug 15;436(16):168640. doi: 10.1016/j.jmb.2024.168640. Epub 2024 Jun 4. J Mol Biol. 2024. PMID: 38844044

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