Oyarzabal J - Search Results

1

Fragment-hopping-based discovery of a novel chemical series of proto-oncogene PIM-1 kinase inhibitors.

Saluste G, Albarran MI, Alvarez RM, Rabal O, Ortega MA, Blanco C, Kurz G, Salgado A, Pevarello P, Bischoff JR, Pastor J, Oyarzabal J. Saluste G, et al. Among authors: oyarzabal j. PLoS One. 2012;7(10):e45964. doi: 10.1371/journal.pone.0045964. Epub 2012 Oct 24. PLoS One. 2012. PMID: 23115625 Free PMC article.

2

ICAM-1 peptide inhibitors of T-cell adhesion bind to the allosteric site of LFA-1. An NMR characterization.

Zimmerman T, Oyarzabal J, Sebastián ES, Majumdar S, Tejo BA, Siahaan TJ, Blanco FJ. Zimmerman T, et al. Among authors: oyarzabal j. Chem Biol Drug Des. 2007 Oct;70(4):347-53. doi: 10.1111/j.1747-0285.2007.00566.x. Epub 2007 Sep 14. Chem Biol Drug Des. 2007. PMID: 17868072

3

Assessment of additive/nonadditive effects in structure-activity relationships: implications for iterative drug design.

Patel Y, Gillet VJ, Howe T, Pastor J, Oyarzabal J, Willett P. Patel Y, et al. Among authors: oyarzabal j. J Med Chem. 2008 Dec 11;51(23):7552-62. doi: 10.1021/jm801070q. J Med Chem. 2008. PMID: 19012393

4

Novel approach for chemotype hopping based on annotated databases of chemically feasible fragments and a prospective case study: new melanin concentrating hormone antagonists.

Oyarzabal J, Howe T, Alcazar J, Andrés JI, Alvarez RM, Dautzenberg F, Iturrino L, Martínez S, Van der Linden I. Oyarzabal J, et al. J Med Chem. 2009 Apr 9;52(7):2076-89. doi: 10.1021/jm8016199. J Med Chem. 2009. PMID: 19290642

5

Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases.

Link W, Oyarzabal J, Serelde BG, Albarran MI, Rabal O, Cebriá A, Alfonso P, Fominaya J, Renner O, Peregrina S, Soilán D, Ceballos PA, Hernández AI, Lorenzo M, Pevarello P, Granda TG, Kurz G, Carnero A, Bischoff JR. Link W, et al. Among authors: oyarzabal j. J Biol Chem. 2009 Oct 9;284(41):28392-28400. doi: 10.1074/jbc.M109.038984. Epub 2009 Aug 18. J Biol Chem. 2009. PMID: 19690175 Free PMC article.

6

Optimizing the performance of in silico ADMET general models according to local requirements: MARS approach. solubility estimations as case study.

Oyarzabal J, Pastor J, Howe TJ. Oyarzabal J, et al. J Chem Inf Model. 2009 Dec;49(12):2837-50. doi: 10.1021/ci900308u. J Chem Inf Model. 2009. PMID: 19919041

7

An integrated one-step system to extract, analyze and annotate all relevant information from image-based cell screening of chemical libraries.

Rabal O, Link W, Serelde BG, Bischoff JR, Oyarzabal J. Rabal O, et al. Among authors: oyarzabal j. Mol Biosyst. 2010 Apr;6(4):711-20. doi: 10.1039/b919830j. Epub 2010 Jan 21. Mol Biosyst. 2010. PMID: 20237649

8

Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach.

Oyarzabal J, Zarich N, Albarran MI, Palacios I, Urbano-Cuadrado M, Mateos G, Reymundo I, Rabal O, Salgado A, Corrionero A, Fominaya J, Pastor J, Bischoff JR. Oyarzabal J, et al. J Med Chem. 2010 Sep 23;53(18):6618-28. doi: 10.1021/jm1005513. J Med Chem. 2010. PMID: 20722422

9

Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition.

Blanco-Aparicio C, Collazo AM, Oyarzabal J, Leal JF, Albarán MI, Lima FR, Pequeño B, Ajenjo N, Becerra M, Alfonso P, Reymundo MI, Palacios I, Mateos G, Quiñones H, Corrionero A, Carnero A, Pevarello P, Lopez AR, Fominaya J, Pastor J, Bischoff JR. Blanco-Aparicio C, et al. Among authors: oyarzabal j. Cancer Lett. 2011 Jan 28;300(2):145-53. doi: 10.1016/j.canlet.2010.09.016. Epub 2010 Nov 3. Cancer Lett. 2011. PMID: 21051136

10

Centralizing discovery information: from logistics to knowledge at a public organization.

Urbano-Cuadrado M, Rabal O, Oyarzabal J. Urbano-Cuadrado M, et al. Among authors: oyarzabal j. Comb Chem High Throughput Screen. 2011 Jul;14(6):429-49. doi: 10.2174/138620711795767848. Comb Chem High Throughput Screen. 2011. PMID: 21143181

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