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Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.
O'Neill HC, Laverty DC, Patzlaff NE, Cohen BN, Fonck C, McKinney S, McIntosh JM, Lindstrom JM, Lester HA, Grady SR, Marks MJ. O'Neill HC, et al. Among authors: marks mj. Pharmacol Biochem Behav. 2013 Jan;103(3):603-21. doi: 10.1016/j.pbb.2012.10.014. Epub 2012 Nov 1. Pharmacol Biochem Behav. 2013. PMID: 23123803 Free PMC article.
Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2*-, alpha 6 beta 2*-, alpha 3 beta 4*- and alpha 7-nicotine acetylcholine receptors.
Grady SR, Drenan RM, Breining SR, Yohannes D, Wageman CR, Fedorov NB, McKinney S, Whiteaker P, Bencherif M, Lester HA, Marks MJ. Grady SR, et al. Among authors: marks mj. Neuropharmacology. 2010 Jun;58(7):1054-66. doi: 10.1016/j.neuropharm.2010.01.013. Epub 2010 Jan 28. Neuropharmacology. 2010. PMID: 20114055 Free PMC article.
211 results