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ACAT inhibition reduces the progression of preexisting, advanced atherosclerotic mouse lesions without plaque or systemic toxicity.
Rong JX, Blachford C, Feig JE, Bander I, Mayne J, Kusunoki J, Miller C, Davis M, Wilson M, Dehn S, Thorp E, Tabas I, Taubman MB, Rudel LL, Fisher EA. Rong JX, et al. Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):4-12. doi: 10.1161/ATVBAHA.112.252056. Epub 2012 Nov 8. Arterioscler Thromb Vasc Biol. 2013. PMID: 23139293 Free PMC article.
High-density lipoproteins retard the progression of atherosclerosis and favorably remodel lesions without suppressing indices of inflammation or oxidation.
Choudhury RP, Rong JX, Trogan E, Elmalem VI, Dansky HM, Breslow JL, Witztum JL, Fallon JT, Fisher EA. Choudhury RP, et al. Among authors: rong jx. Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1904-9. doi: 10.1161/01.ATV.0000142808.34602.25. Epub 2004 Aug 19. Arterioscler Thromb Vasc Biol. 2004. PMID: 15319266
27 results