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Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.
Torres M, Jimenez S, Sanchez-Varo R, Navarro V, Trujillo-Estrada L, Sanchez-Mejias E, Carmona I, Davila JC, Vizuete M, Gutierrez A, Vitorica J. Torres M, et al. Among authors: navarro v. Mol Neurodegener. 2012 Nov 22;7:59. doi: 10.1186/1750-1326-7-59. Mol Neurodegener. 2012. PMID: 23173743 Free PMC article.
In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.
Trujillo-Estrada L, Jimenez S, De Castro V, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, Navarro V, Sanchez-Varo R, Sanchez-Mejias E, Davila JC, Vizuete M, Gutierrez A, Vitorica J. Trujillo-Estrada L, et al. Among authors: navarro v. Acta Neuropathol Commun. 2013 Nov 12;1:73. doi: 10.1186/2051-5960-1-73. Acta Neuropathol Commun. 2013. PMID: 24252759 Free PMC article.
Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.
Sanchez-Mejias E, Navarro V, Jimenez S, Sanchez-Mico M, Sanchez-Varo R, Nuñez-Diaz C, Trujillo-Estrada L, Davila JC, Vizuete M, Gutierrez A, Vitorica J. Sanchez-Mejias E, et al. Among authors: navarro v. Acta Neuropathol. 2016 Dec;132(6):897-916. doi: 10.1007/s00401-016-1630-5. Epub 2016 Oct 14. Acta Neuropathol. 2016. PMID: 27743026 Free PMC article.
Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer's disease.
Baglietto-Vargas D, Sánchez-Mejias E, Navarro V, Jimenez S, Trujillo-Estrada L, Gómez-Arboledas A, Sánchez-Mico M, Sánchez-Varo R, Vizuete M, Dávila JC, García-Verdugo JM, Vitorica J, Gutierrez A. Baglietto-Vargas D, et al. Among authors: navarro v. Sci Rep. 2017 Aug 30;7(1):10085. doi: 10.1038/s41598-017-10353-7. Sci Rep. 2017. PMID: 28855626 Free PMC article.
Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease.
Gomez-Arboledas A, Davila JC, Sanchez-Mejias E, Navarro V, Nuñez-Diaz C, Sanchez-Varo R, Sanchez-Mico MV, Trujillo-Estrada L, Fernandez-Valenzuela JJ, Vizuete M, Comella JX, Galea E, Vitorica J, Gutierrez A. Gomez-Arboledas A, et al. Among authors: navarro v. Glia. 2018 Mar;66(3):637-653. doi: 10.1002/glia.23270. Epub 2017 Nov 27. Glia. 2018. PMID: 29178139 Free PMC article.
Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative.
Navarro V, Sanchez-Mejias E, Jimenez S, Muñoz-Castro C, Sanchez-Varo R, Davila JC, Vizuete M, Gutierrez A, Vitorica J. Navarro V, et al. Front Aging Neurosci. 2018 May 11;10:140. doi: 10.3389/fnagi.2018.00140. eCollection 2018. Front Aging Neurosci. 2018. PMID: 29867449 Free PMC article.
Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology.
Romero-Molina C, Navarro V, Sanchez-Varo R, Jimenez S, Fernandez-Valenzuela JJ, Sanchez-Mico MV, Muñoz-Castro C, Gutierrez A, Vitorica J, Vizuete M. Romero-Molina C, et al. Among authors: navarro v. Front Cell Neurosci. 2018 Nov 14;12:421. doi: 10.3389/fncel.2018.00421. eCollection 2018. Front Cell Neurosci. 2018. PMID: 30487735 Free PMC article.
1,096 results