Botas J - Search Results

1

A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.

Miller JP, Yates BE, Al-Ramahi I, Berman AE, Sanhueza M, Kim E, de Haro M, DeGiacomo F, Torcassi C, Holcomb J, Gafni J, Mooney SD, Botas J, Ellerby LM, Hughes RE. Miller JP, et al. Among authors: botas j. PLoS Genet. 2012;8(11):e1003042. doi: 10.1371/journal.pgen.1003042. Epub 2012 Nov 29. PLoS Genet. 2012. PMID: 23209424 Free PMC article.

2

MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1.

de Haro M, Al-Ramahi I, De Gouyon B, Ukani L, Rosa A, Faustino NA, Ashizawa T, Cooper TA, Botas J. de Haro M, et al. Among authors: botas j. Hum Mol Genet. 2006 Jul 1;15(13):2138-45. doi: 10.1093/hmg/ddl137. Epub 2006 May 24. Hum Mol Genet. 2006. PMID: 16723374

3

CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation.

Al-Ramahi I, Lam YC, Chen HK, de Gouyon B, Zhang M, Pérez AM, Branco J, de Haro M, Patterson C, Zoghbi HY, Botas J. Al-Ramahi I, et al. Among authors: botas j. J Biol Chem. 2006 Sep 8;281(36):26714-24. doi: 10.1074/jbc.M601603200. Epub 2006 Jul 10. J Biol Chem. 2006. PMID: 16831871 Free article.

4

Huntingtin interacting proteins are genetic modifiers of neurodegeneration.

Kaltenbach LS, Romero E, Becklin RR, Chettier R, Bell R, Phansalkar A, Strand A, Torcassi C, Savage J, Hurlburt A, Cha GH, Ukani L, Chepanoske CL, Zhen Y, Sahasrabudhe S, Olson J, Kurschner C, Ellerby LM, Peltier JM, Botas J, Hughes RE. Kaltenbach LS, et al. Among authors: botas j. PLoS Genet. 2007 May 11;3(5):e82. doi: 10.1371/journal.pgen.0030082. PLoS Genet. 2007. PMID: 17500595 Free PMC article.

5

Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases.

Branco J, Al-Ramahi I, Ukani L, Pérez AM, Fernandez-Funez P, Rincón-Limas D, Botas J. Branco J, et al. Among authors: botas j. Hum Mol Genet. 2008 Feb 1;17(3):376-90. doi: 10.1093/hmg/ddm315. Epub 2007 Nov 5. Hum Mol Genet. 2008. PMID: 17984172

6

dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1.

Al-Ramahi I, Pérez AM, Lim J, Zhang M, Sorensen R, de Haro M, Branco J, Pulst SM, Zoghbi HY, Botas J. Al-Ramahi I, et al. Among authors: botas j. PLoS Genet. 2007 Dec 28;3(12):e234. doi: 10.1371/journal.pgen.0030234. Epub 2007 Nov 16. PLoS Genet. 2007. PMID: 18166084 Free PMC article.

7

Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm.

Romero E, Cha GH, Verstreken P, Ly CV, Hughes RE, Bellen HJ, Botas J. Romero E, et al. Among authors: botas j. Neuron. 2008 Jan 10;57(1):27-40. doi: 10.1016/j.neuron.2007.11.025. Neuron. 2008. PMID: 18184562 Free PMC article.

8

Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease.

Miller JP, Holcomb J, Al-Ramahi I, de Haro M, Gafni J, Zhang N, Kim E, Sanhueza M, Torcassi C, Kwak S, Botas J, Hughes RE, Ellerby LM. Miller JP, et al. Among authors: botas j. Neuron. 2010 Jul 29;67(2):199-212. doi: 10.1016/j.neuron.2010.06.021. Neuron. 2010. PMID: 20670829 Free PMC article.

9

Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity.

Zhang N, Li B, Al-Ramahi I, Cong X, Held JM, Kim E, Botas J, Gibson BW, Ellerby LM. Zhang N, et al. Among authors: botas j. J Biol Chem. 2012 Jun 15;287(25):21204-13. doi: 10.1074/jbc.M111.321661. Epub 2012 Apr 16. J Biol Chem. 2012. PMID: 22511757 Free PMC article.

10

Network organization of the huntingtin proteomic interactome in mammalian brain.

Shirasaki DI, Greiner ER, Al-Ramahi I, Gray M, Boontheung P, Geschwind DH, Botas J, Coppola G, Horvath S, Loo JA, Yang XW. Shirasaki DI, et al. Among authors: botas j. Neuron. 2012 Jul 12;75(1):41-57. doi: 10.1016/j.neuron.2012.05.024. Neuron. 2012. PMID: 22794259 Free PMC article.

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