Dbouk HA - Search Results

1

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.

Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM. Dbouk HA, et al. Sci Signal. 2012 Dec 4;5(253):ra89. doi: 10.1126/scisignal.2003264. Sci Signal. 2012. PMID: 23211529 Free PMC article.

2

A beta version of life: p110β takes center stage.

Dbouk HA, Backer JM. Dbouk HA, et al. Oncotarget. 2010 Dec;1(8):729-733. doi: 10.18632/oncotarget.207. Oncotarget. 2010. PMID: 21321382 Free PMC article. Review.

3

Novel approaches to inhibitor design for the p110β phosphoinositide 3-kinase.

Dbouk HA, Backer JM. Dbouk HA, et al. Trends Pharmacol Sci. 2013 Mar;34(3):149-53. doi: 10.1016/j.tips.2012.12.004. Epub 2013 Feb 12. Trends Pharmacol Sci. 2013. PMID: 23411347 Free PMC article. Review.

4

Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase.

Dbouk HA, Khalil BD, Wu H, Shymanets A, Nürnberg B, Backer JM. Dbouk HA, et al. PLoS One. 2013 May 29;8(5):e63833. doi: 10.1371/journal.pone.0063833. Print 2013. PLoS One. 2013. PMID: 23734178 Free PMC article.

5

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs).

Vadas O, Dbouk HA, Shymanets A, Perisic O, Burke JE, Abi Saab WF, Khalil BD, Harteneck C, Bresnick AR, Nürnberg B, Backer JM, Williams RL. Vadas O, et al. Among authors: dbouk ha. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18862-7. doi: 10.1073/pnas.1304801110. Epub 2013 Nov 4. Proc Natl Acad Sci U S A. 2013. PMID: 24190998 Free PMC article.

6

Identification of the Rab5 binding site in p110β: assays for PI3Kβ binding to Rab5.

Salamon RS, Dbouk HA, Collado D, Lopiccolo J, Bresnick AR, Backer JM. Salamon RS, et al. Among authors: dbouk ha. Methods Mol Biol. 2015;1298:271-81. doi: 10.1007/978-1-4939-2569-8_23. Methods Mol Biol. 2015. PMID: 25800850 Free PMC article.

7

A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase.

Dbouk HA, Pang H, Fiser A, Backer JM. Dbouk HA, et al. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19897-902. doi: 10.1073/pnas.1008739107. Epub 2010 Oct 28. Proc Natl Acad Sci U S A. 2010. PMID: 21030680 Free PMC article.

8

PI3Kβ downstream of GPCRs - crucial partners in oncogenesis.

Dbouk HA, Vadas O, Williams RL, Backer JM. Dbouk HA, et al. Oncotarget. 2012 Dec;3(12):1485-6. doi: 10.18632/oncotarget.787. Oncotarget. 2012. PMID: 23328076 Free PMC article. No abstract available.

9

Class IA PI3K p110β subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation.

Dou Z, Pan JA, Dbouk HA, Ballou LM, DeLeon JL, Fan Y, Chen JS, Liang Z, Li G, Backer JM, Lin RZ, Zong WX. Dou Z, et al. Among authors: dbouk ha. Mol Cell. 2013 Apr 11;50(1):29-42. doi: 10.1016/j.molcel.2013.01.022. Epub 2013 Feb 21. Mol Cell. 2013. PMID: 23434372 Free PMC article.

10

Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation.

Jaiswal BS, Janakiraman V, Kljavin NM, Chaudhuri S, Stern HM, Wang W, Kan Z, Dbouk HA, Peters BA, Waring P, Dela Vega T, Kenski DM, Bowman KK, Lorenzo M, Li H, Wu J, Modrusan Z, Stinson J, Eby M, Yue P, Kaminker JS, de Sauvage FJ, Backer JM, Seshagiri S. Jaiswal BS, et al. Among authors: dbouk ha. Cancer Cell. 2009 Dec 8;16(6):463-74. doi: 10.1016/j.ccr.2009.10.016. Cancer Cell. 2009. PMID: 19962665 Free PMC article.

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