Harden TK - Search Results

1

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.

Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM. Dbouk HA, et al. Among authors: harden tk. Sci Signal. 2012 Dec 4;5(253):ra89. doi: 10.1126/scisignal.2003264. Sci Signal. 2012. PMID: 23211529 Free PMC article.

2

Agonist binding and Gq-stimulating activities of the purified human P2Y1 receptor.

Waldo GL, Harden TK. Waldo GL, et al. Among authors: harden tk. Mol Pharmacol. 2004 Feb;65(2):426-36. doi: 10.1124/mol.65.2.426. Mol Pharmacol. 2004. PMID: 14742685

3

Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodes.

Harden TK, Waldo GL, Hicks SN, Sondek J. Harden TK, et al. Chem Rev. 2011 Oct 12;111(10):6120-9. doi: 10.1021/cr200209p. Chem Rev. 2011. PMID: 21988240 Free PMC article. No abstract available.

4

Beta gamma-subunit activation of G-protein-regulated phospholipase C.

Boyer JL, Waldo GL, Harden TK. Boyer JL, et al. Among authors: harden tk. J Biol Chem. 1992 Dec 15;267(35):25451-6. J Biol Chem. 1992. PMID: 1460039 Free article.

5

Molecular cloning and expression of an avian G protein-coupled P2Y receptor.

Boyer JL, Waldo GL, Harden TK. Boyer JL, et al. Among authors: harden tk. Mol Pharmacol. 1997 Dec;52(6):928-34. doi: 10.1124/mol.52.6.928. Mol Pharmacol. 1997. PMID: 9415702

6

A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q.

Singer AU, Waldo GL, Harden TK, Sondek J. Singer AU, et al. Among authors: harden tk. Nat Struct Biol. 2002 Jan;9(1):32-6. doi: 10.1038/nsb731. Nat Struct Biol. 2002. PMID: 11753430

7

Kinetic scaffolding mediated by a phospholipase C-beta and Gq signaling complex.

Waldo GL, Ricks TK, Hicks SN, Cheever ML, Kawano T, Tsuboi K, Wang X, Montell C, Kozasa T, Sondek J, Harden TK. Waldo GL, et al. Among authors: harden tk. Science. 2010 Nov 12;330(6006):974-80. doi: 10.1126/science.1193438. Epub 2010 Oct 21. Science. 2010. PMID: 20966218 Free PMC article.

8

Potent and Selective Peptide-based Inhibition of the G Protein Gαq.

Charpentier TH, Waldo GL, Lowery-Gionta EG, Krajewski K, Strahl BD, Kash TL, Harden TK, Sondek J. Charpentier TH, et al. Among authors: harden tk. J Biol Chem. 2016 Dec 2;291(49):25608-25616. doi: 10.1074/jbc.M116.740407. Epub 2016 Oct 14. J Biol Chem. 2016. PMID: 27742837 Free PMC article.

9

Selective activation of phospholipase C by recombinant G-protein alpha- and beta gamma-subunits.

Boyer JL, Graber SG, Waldo GL, Harden TK, Garrison JC. Boyer JL, et al. Among authors: harden tk. J Biol Chem. 1994 Jan 28;269(4):2814-9. J Biol Chem. 1994. PMID: 8300614 Free article.

10

Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.

Cunningham ML, Waldo GL, Hollinger S, Hepler JR, Harden TK. Cunningham ML, et al. Among authors: harden tk. J Biol Chem. 2001 Feb 23;276(8):5438-44. doi: 10.1074/jbc.M007699200. Epub 2000 Nov 3. J Biol Chem. 2001. PMID: 11063746 Free article.

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