Vadas O - Search Results

1

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.

Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM. Dbouk HA, et al. Among authors: vadas o. Sci Signal. 2012 Dec 4;5(253):ra89. doi: 10.1126/scisignal.2003264. Sci Signal. 2012. PMID: 23211529 Free PMC article.

2

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs).

Vadas O, Dbouk HA, Shymanets A, Perisic O, Burke JE, Abi Saab WF, Khalil BD, Harteneck C, Bresnick AR, Nürnberg B, Backer JM, Williams RL. Vadas O, et al. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18862-7. doi: 10.1073/pnas.1304801110. Epub 2013 Nov 4. Proc Natl Acad Sci U S A. 2013. PMID: 24190998 Free PMC article.

3

Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α.

Burke JE, Vadas O, Berndt A, Finegan T, Perisic O, Williams RL. Burke JE, et al. Among authors: vadas o. Structure. 2011 Aug 10;19(8):1127-37. doi: 10.1016/j.str.2011.06.003. Structure. 2011. PMID: 21827948 Free PMC article.

4

Structural basis for activation and inhibition of class I phosphoinositide 3-kinases.

Vadas O, Burke JE, Zhang X, Berndt A, Williams RL. Vadas O, et al. Sci Signal. 2011 Oct 18;4(195):re2. doi: 10.1126/scisignal.2002165. Sci Signal. 2011. PMID: 22009150 Review.

5

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

Burke JE, Perisic O, Masson GR, Vadas O, Williams RL. Burke JE, et al. Among authors: vadas o. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15259-64. doi: 10.1073/pnas.1205508109. Epub 2012 Sep 4. Proc Natl Acad Sci U S A. 2012. PMID: 22949682 Free PMC article.

6

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.

Shymanets A, Prajwal, Vadas O, Czupalla C, LoPiccolo J, Brenowitz M, Ghigo A, Hirsch E, Krause E, Wetzker R, Williams RL, Harteneck C, Nürnberg B. Shymanets A, et al. Among authors: vadas o. Biochem J. 2015 Jul 1;469(1):59-69. doi: 10.1042/BJ20150099. Biochem J. 2015. PMID: 26173259 Free PMC article.

7

Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism.

Zhang X, Vadas O, Perisic O, Anderson KE, Clark J, Hawkins PT, Stephens LR, Williams RL. Zhang X, et al. Among authors: vadas o. Mol Cell. 2011 Mar 4;41(5):567-78. doi: 10.1016/j.molcel.2011.01.026. Mol Cell. 2011. PMID: 21362552 Free PMC article.

8

PI3Kβ downstream of GPCRs - crucial partners in oncogenesis.

Dbouk HA, Vadas O, Williams RL, Backer JM. Dbouk HA, et al. Among authors: vadas o. Oncotarget. 2012 Dec;3(12):1485-6. doi: 10.18632/oncotarget.787. Oncotarget. 2012. PMID: 23328076 Free PMC article. No abstract available.

9

Probing the dynamic regulation of peripheral membrane proteins using hydrogen deuterium exchange-MS (HDX-MS).

Vadas O, Burke JE. Vadas O, et al. Biochem Soc Trans. 2015 Oct;43(5):773-86. doi: 10.1042/BST20150065. Biochem Soc Trans. 2015. PMID: 26517882 Review.

10

Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils.

Rynkiewicz NK, Anderson KE, Suire S, Collins DM, Karanasios E, Vadas O, Williams R, Oxley D, Clark J, Stephens LR, Hawkins PT. Rynkiewicz NK, et al. Among authors: vadas o. Sci Signal. 2020 Nov 3;13(656):eaaz4003. doi: 10.1126/scisignal.aaz4003. Sci Signal. 2020. PMID: 33144519 Free PMC article.

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