Preu L - Search Results

1

3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3.

Fugel W, Oberholzer AE, Gschloessl B, Dzikowski R, Pressburger N, Preu L, Pearl LH, Baratte B, Ratin M, Okun I, Doerig C, Kruggel S, Lemcke T, Meijer L, Kunick C. Fugel W, et al. Among authors: preu l. J Med Chem. 2013 Jan 10;56(1):264-75. doi: 10.1021/jm301575n. Epub 2012 Dec 27. J Med Chem. 2013. PMID: 23214499

2

Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH).

Becker A, Kohfeld S, Lader A, Preu L, Pies T, Wieking K, Ferandin Y, Knockaert M, Meijer L, Kunick C. Becker A, et al. Among authors: preu l. Eur J Med Chem. 2010 Jan;45(1):335-42. doi: 10.1016/j.ejmech.2009.10.018. Epub 2009 Oct 14. Eur J Med Chem. 2010. PMID: 19906467

3

Inhibitors of the RET tyrosine kinase based on a 2-(alkylsulfanyl)-4-(3-thienyl)nicotinonitrile scaffold.

Brandt W, Mologni L, Preu L, Lemcke T, Gambacorti-Passerini C, Kunick C. Brandt W, et al. Among authors: preu l. Eur J Med Chem. 2010 Jul;45(7):2919-27. doi: 10.1016/j.ejmech.2010.03.017. Epub 2010 Mar 19. Eur J Med Chem. 2010. PMID: 20409618

4

Dual IGF-1R/SRC inhibitors based on a N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure.

Schmidt S, Preu L, Lemcke T, Totzke F, Schächtele C, Kubbutat MH, Kunick C. Schmidt S, et al. Among authors: preu l. Eur J Med Chem. 2011 Jul;46(7):2759-69. doi: 10.1016/j.ejmech.2011.03.065. Epub 2011 Apr 6. Eur J Med Chem. 2011. PMID: 21524503

5

10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.

Falke H, Chaikuad A, Becker A, Loaëc N, Lozach O, Abu Jhaisha S, Becker W, Jones PG, Preu L, Baumann K, Knapp S, Meijer L, Kunick C. Falke H, et al. Among authors: preu l. J Med Chem. 2015 Apr 9;58(7):3131-43. doi: 10.1021/jm501994d. Epub 2015 Mar 23. J Med Chem. 2015. PMID: 25730262 Free PMC article.

6

Identification of 2-anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as dual PLK1/VEGF-R2 kinase inhibitor chemotypes by structure-based lead generation.

Egert-Schmidt AM, Dreher J, Dunkel U, Kohfeld S, Preu L, Weber H, Ehlert JE, Mutschler B, Totzke F, Schächtele C, Kubbutat MH, Baumann K, Kunick C. Egert-Schmidt AM, et al. Among authors: preu l. J Med Chem. 2010 Mar 25;53(6):2433-42. doi: 10.1021/jm901388c. J Med Chem. 2010. PMID: 20170163

7

2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines.

Determann R, Dreher J, Baumann K, Preu L, Jones PG, Totzke F, Schächtele C, Kubbutat MH, Kunick C. Determann R, et al. Among authors: preu l. Eur J Med Chem. 2012 Jul;53:254-63. doi: 10.1016/j.ejmech.2012.04.007. Epub 2012 Apr 14. Eur J Med Chem. 2012. PMID: 22560627

8

2-Arylpaullones are selective antitrypanosomal agents.

Ryczak J, Papini M, Lader A, Nasereddin A, Kopelyanskiy D, Preu L, Jaffe CL, Kunick C. Ryczak J, et al. Among authors: preu l. Eur J Med Chem. 2013 Jun;64:396-400. doi: 10.1016/j.ejmech.2013.03.065. Epub 2013 Apr 10. Eur J Med Chem. 2013. PMID: 23648975

9

9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma.

Maiwald F, Benítez D, Charquero D, Dar MA, Erdmann H, Preu L, Koch O, Hölscher C, Loaëc N, Meijer L, Comini MA, Kunick C. Maiwald F, et al. Among authors: preu l. Eur J Med Chem. 2014 Aug 18;83:274-83. doi: 10.1016/j.ejmech.2014.06.020. Epub 2014 Jun 11. Eur J Med Chem. 2014. PMID: 24973661

10

Novel 2-Phenoxyanilide Congeners Derived from a Hit Structure of the TCAMS: Synthesis and Evaluation of Their in Vitro Activity against Plasmodium falciparum.

Weidner T, Nasereddin A, Preu L, Grünefeld J, Dzikowski R, Kunick C. Weidner T, et al. Among authors: preu l. Molecules. 2016 Feb 17;21(2):223. doi: 10.3390/molecules21020223. Molecules. 2016. PMID: 26901174 Free PMC article.

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