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6-methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 discovery of a potent and selective α1D-adrenoceptor antagonist.
Fumagalli L, Pallavicini M, Budriesi R, Bolchi C, Canovi M, Chiarini A, Chiodini G, Gobbi M, Laurino P, Micucci M, Straniero V, Valoti E. Fumagalli L, et al. Among authors: micucci m. J Med Chem. 2013 Aug 22;56(16):6402-12. doi: 10.1021/jm400867d. Epub 2013 Jul 31. J Med Chem. 2013. PMID: 23902232
Playing with opening and closing of heterocycles: using the cusmano-ruccia reaction to develop a novel class of oxadiazolothiazinones, active as calcium channel modulators and P-glycoprotein inhibitors.
Spinelli D, Budriesi R, Cosimelli B, Severi E, Micucci M, Baroni M, Fusi F, Ioan P, Cross S, Frosini M, Saponara S, Matucci R, Rosano C, Viale M, Chiarini A, Carosati E. Spinelli D, et al. Among authors: micucci m. Molecules. 2014 Oct 14;19(10):16543-72. doi: 10.3390/molecules191016543. Molecules. 2014. PMID: 25317581 Free PMC article.
71 results