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Page 1
Constitutive HER2 signaling promotes breast cancer metastasis through cellular senescence.
Angelini PD, Zacarias Fluck MF, Pedersen K, Parra-Palau JL, Guiu M, Bernadó Morales C, Vicario R, Luque-García A, Navalpotro NP, Giralt J, Canals F, Gomis RR, Tabernero J, Baselga J, Villanueva J, Arribas J. Angelini PD, et al. Cancer Res. 2013 Jan 1;73(1):450-8. doi: 10.1158/0008-5472.CAN-12-2301. Cancer Res. 2013. PMID: 23288917
A major role of p95/611-CTF, a carboxy-terminal fragment of HER2, in the down-modulation of the estrogen receptor in HER2-positive breast cancers.
Parra-Palau JL, Pedersen K, Peg V, Scaltriti M, Angelini PD, Escorihuela M, Mancilla S, Sánchez Pla A, Ramón Y Cajal S, Baselga J, Arribas J. Parra-Palau JL, et al. Among authors: angelini pd. Cancer Res. 2010 Nov 1;70(21):8537-46. doi: 10.1158/0008-5472.CAN-10-1701. Epub 2010 Oct 26. Cancer Res. 2010. PMID: 20978202
A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis.
Pedersen K, Angelini PD, Laos S, Bach-Faig A, Cunningham MP, Ferrer-Ramón C, Luque-García A, García-Castillo J, Parra-Palau JL, Scaltriti M, Ramón y Cajal S, Baselga J, Arribas J. Pedersen K, et al. Among authors: angelini pd. Mol Cell Biol. 2009 Jun;29(12):3319-31. doi: 10.1128/MCB.01803-08. Epub 2009 Apr 13. Mol Cell Biol. 2009. PMID: 19364815 Free PMC article.
HER2 carboxyl-terminal fragments regulate cell migration and cortactin phosphorylation.
García-Castillo J, Pedersen K, Angelini PD, Bech-Serra JJ, Colomé N, Cunningham MP, Parra-Palau JL, Canals F, Baselga J, Arribas J. García-Castillo J, et al. Among authors: angelini pd. J Biol Chem. 2009 Sep 11;284(37):25302-13. doi: 10.1074/jbc.M109.001982. Epub 2009 Jul 8. J Biol Chem. 2009. PMID: 19589785 Free PMC article.
Clinical benefit of lapatinib-based therapy in patients with human epidermal growth factor receptor 2-positive breast tumors coexpressing the truncated p95HER2 receptor.
Scaltriti M, Chandarlapaty S, Prudkin L, Aura C, Jimenez J, Angelini PD, Sánchez G, Guzman M, Parra JL, Ellis C, Gagnon R, Koehler M, Gomez H, Geyer C, Cameron D, Arribas J, Rosen N, Baselga J. Scaltriti M, et al. Among authors: angelini pd. Clin Cancer Res. 2010 May 1;16(9):2688-95. doi: 10.1158/1078-0432.CCR-09-3407. Epub 2010 Apr 20. Clin Cancer Res. 2010. PMID: 20406840 Free PMC article.