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A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus.
Prokunina-Olsson L, Muchmore B, Tang W, Pfeiffer RM, Park H, Dickensheets H, Hergott D, Porter-Gill P, Mumy A, Kohaar I, Chen S, Brand N, Tarway M, Liu L, Sheikh F, Astemborski J, Bonkovsky HL, Edlin BR, Howell CD, Morgan TR, Thomas DL, Rehermann B, Donnelly RP, O'Brien TR. Prokunina-Olsson L, et al. Among authors: howell cd. Nat Genet. 2013 Feb;45(2):164-71. doi: 10.1038/ng.2521. Epub 2013 Jan 6. Nat Genet. 2013. PMID: 23291588 Free PMC article.
Comparison of functional variants in IFNL4 and IFNL3 for association with HCV clearance.
O'Brien TR, Pfeiffer RM, Paquin A, Lang Kuhs KA, Chen S, Bonkovsky HL, Edlin BR, Howell CD, Kirk GD, Kuniholm MH, Morgan TR, Strickler HD, Thomas DL, Prokunina-Olsson L. O'Brien TR, et al. Among authors: howell cd. J Hepatol. 2015 Nov;63(5):1103-10. doi: 10.1016/j.jhep.2015.06.035. Epub 2015 Jul 15. J Hepatol. 2015. PMID: 26186989 Free PMC article.
Vitamin D Status and Virologic Response to HCV Therapy in the HALT-C and VIRAHEP-C Trials.
Loftfield E, O'Brien TR, Pfeiffer RM, Howell CD, Horst R, Prokunina-Olsson L, Weinstein SJ, Albanes D, Morgan TR, Freedman ND. Loftfield E, et al. Among authors: howell cd. PLoS One. 2016 Nov 10;11(11):e0166036. doi: 10.1371/journal.pone.0166036. eCollection 2016. PLoS One. 2016. PMID: 27832143 Free PMC article. Clinical Trial.
A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infection.
Huang Y, Yang H, Borg BB, Su X, Rhodes SL, Yang K, Tong X, Tang G, Howell CD, Rosen HR, Thio CL, Thomas DL, Alter HJ, Sapp RK, Liang TJ. Huang Y, et al. Among authors: howell cd. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):985-90. doi: 10.1073/pnas.0609954104. Epub 2007 Jan 10. Proc Natl Acad Sci U S A. 2007. PMID: 17215375 Free PMC article.
Diagnosis, management, and treatment of hepatitis C: an update.
Ghany MG, Strader DB, Thomas DL, Seeff LB; American Association for the Study of Liver Diseases. Ghany MG, et al. Hepatology. 2009 Apr;49(4):1335-74. doi: 10.1002/hep.22759. Hepatology. 2009. PMID: 19330875 Free PMC article. No abstract available.
88 results