O'Rahilly S - Search Results

1

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.

McMurray F, Church CD, Larder R, Nicholson G, Wells S, Teboul L, Tung YC, Rimmington D, Bosch F, Jimenez V, Yeo GS, O'Rahilly S, Ashcroft FM, Coll AP, Cox RD. McMurray F, et al. PLoS Genet. 2013;9(1):e1003166. doi: 10.1371/journal.pgen.1003166. Epub 2013 Jan 3. PLoS Genet. 2013. PMID: 23300482 Free PMC article.

2

Obesity therapy: altering the energy intake-and-expenditure balance sheet.

Crowley VE, Yeo GS, O'Rahilly S. Crowley VE, et al. Nat Rev Drug Discov. 2002 Apr;1(4):276-86. doi: 10.1038/nrd770. Nat Rev Drug Discov. 2002. PMID: 12120279 Review.

3

Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids.

Coll AP, Challis BG, López M, Piper S, Yeo GS, O'Rahilly S. Coll AP, et al. Diabetes. 2005 Aug;54(8):2269-76. doi: 10.2337/diabetes.54.8.2269. Diabetes. 2005. PMID: 16046291

4

A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance.

Lee YS, Challis BG, Thompson DA, Yeo GS, Keogh JM, Madonna ME, Wraight V, Sims M, Vatin V, Meyre D, Shield J, Burren C, Ibrahim Z, Cheetham T, Swift P, Blackwood A, Hung CC, Wareham NJ, Froguel P, Millhauser GL, O'Rahilly S, Farooqi IS. Lee YS, et al. Cell Metab. 2006 Feb;3(2):135-40. doi: 10.1016/j.cmet.2006.01.006. Cell Metab. 2006. PMID: 16459314 Free article.

5

Peripheral administration of the N-terminal pro-opiomelanocortin fragment 1-28 to Pomc-/- mice reduces food intake and weight but does not affect adrenal growth or corticosterone production.

Coll AP, Fassnacht M, Klammer S, Hahner S, Schulte DM, Piper S, Tung YC, Challis BG, Weinstein Y, Allolio B, O'Rahilly S, Beuschlein F. Coll AP, et al. J Endocrinol. 2006 Aug;190(2):515-25. doi: 10.1677/joe.1.06749. J Endocrinol. 2006. PMID: 16899584 Free PMC article.

6

A comparative study of the central effects of specific proopiomelancortin (POMC)-derived melanocortin peptides on food intake and body weight in pomc null mice.

Tung YC, Piper SJ, Yeung D, O'Rahilly S, Coll AP. Tung YC, et al. Endocrinology. 2006 Dec;147(12):5940-7. doi: 10.1210/en.2006-0866. Epub 2006 Sep 7. Endocrinology. 2006. PMID: 16959830 Free PMC article.

7

Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene.

Gray J, Yeo GS, Cox JJ, Morton J, Adlam AL, Keogh JM, Yanovski JA, El Gharbawy A, Han JC, Tung YC, Hodges JR, Raymond FL, O'rahilly S, Farooqi IS. Gray J, et al. Diabetes. 2006 Dec;55(12):3366-71. doi: 10.2337/db06-0550. Diabetes. 2006. PMID: 17130481 Free PMC article.

8

The hormonal control of food intake.

Coll AP, Farooqi IS, O'Rahilly S. Coll AP, et al. Cell. 2007 Apr 20;129(2):251-62. doi: 10.1016/j.cell.2007.04.001. Cell. 2007. PMID: 17448988 Free PMC article. Review.

9

Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation.

Heisler LK, Pronchuk N, Nonogaki K, Zhou L, Raber J, Tung L, Yeo GS, O'Rahilly S, Colmers WF, Elmquist JK, Tecott LH. Heisler LK, et al. J Neurosci. 2007 Jun 27;27(26):6956-64. doi: 10.1523/JNEUROSCI.2584-06.2007. J Neurosci. 2007. PMID: 17596444 Free PMC article.

10

Pro-opiomelanocortin modulates the thermogenic and physical activity responses to high-fat feeding and markedly influences dietary fat preference.

Tung YC, Rimmington D, O'Rahilly S, Coll AP. Tung YC, et al. Endocrinology. 2007 Nov;148(11):5331-8. doi: 10.1210/en.2007-0797. Epub 2007 Aug 23. Endocrinology. 2007. PMID: 17717049 Free PMC article.

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