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Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism.
Pieretti S, Haanstra JR, Mazet M, Perozzo R, Bergamini C, Prati F, Fato R, Lenaz G, Capranico G, Brun R, Bakker BM, Michels PA, Scapozza L, Bolognesi ML, Cavalli A. Pieretti S, et al. Among authors: capranico g. PLoS Negl Trop Dis. 2013;7(1):e2012. doi: 10.1371/journal.pntd.0002012. Epub 2013 Jan 17. PLoS Negl Trop Dis. 2013. PMID: 23350008 Free PMC article.
G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent.
Tonelli R, Sartini R, Fronza R, Freccero F, Franzoni M, Dongiovanni D, Ballarini M, Ferrari S, D'Apolito M, Di Cola G, Capranico G, Khobta A, Campanini R, Paolucci P, Minucci S, Pession A. Tonelli R, et al. Among authors: capranico g. Leukemia. 2006 Jul;20(7):1307-10. doi: 10.1038/sj.leu.2404221. Epub 2006 Apr 13. Leukemia. 2006. PMID: 16617320 No abstract available.
Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives.
Amato J, Morigi R, Pagano B, Pagano A, Ohnmacht S, De Magis A, Tiang YP, Capranico G, Locatelli A, Graziadio A, Leoni A, Rambaldi M, Novellino E, Neidle S, Randazzo A. Amato J, et al. Among authors: capranico g. J Med Chem. 2016 Jun 23;59(12):5706-20. doi: 10.1021/acs.jmedchem.6b00129. Epub 2016 Jun 6. J Med Chem. 2016. PMID: 27223049
Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?
Amato J, Pagano A, Cosconati S, Amendola G, Fotticchia I, Iaccarino N, Marinello J, De Magis A, Capranico G, Novellino E, Pagano B, Randazzo A. Amato J, et al. Among authors: capranico g. Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1271-1280. doi: 10.1016/j.bbagen.2016.11.008. Epub 2016 Nov 9. Biochim Biophys Acta Gen Subj. 2017. PMID: 27836755
142 results