Hockings C - Search Results

1

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.

Czabotar PE, Westphal D, Dewson G, Ma S, Hockings C, Fairlie WD, Lee EF, Yao S, Robin AY, Smith BJ, Huang DC, Kluck RM, Adams JM, Colman PM. Czabotar PE, et al. Among authors: hockings c. Cell. 2013 Jan 31;152(3):519-31. doi: 10.1016/j.cell.2012.12.031. Cell. 2013. PMID: 23374347 Free article.

2

Bax dimerizes via a symmetric BH3:groove interface during apoptosis.

Dewson G, Ma S, Frederick P, Hockings C, Tan I, Kratina T, Kluck RM. Dewson G, et al. Among authors: hockings c. Cell Death Differ. 2012 Apr;19(4):661-70. doi: 10.1038/cdd.2011.138. Epub 2011 Oct 21. Cell Death Differ. 2012. PMID: 22015607 Free PMC article.

3

Assembly of the Bak apoptotic pore: a critical role for the Bak protein α6 helix in the multimerization of homodimers during apoptosis.

Ma S, Hockings C, Anwari K, Kratina T, Fennell S, Lazarou M, Ryan MT, Kluck RM, Dewson G. Ma S, et al. Among authors: hockings c. J Biol Chem. 2013 Sep 6;288(36):26027-26038. doi: 10.1074/jbc.M113.490094. Epub 2013 Jul 26. J Biol Chem. 2013. PMID: 23893415 Free PMC article.

4

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.

Hockings C, Anwari K, Ninnis RL, Brouwer J, O'Hely M, Evangelista M, Hinds MG, Czabotar PE, Lee EF, Fairlie WD, Dewson G, Kluck RM. Hockings C, et al. Cell Death Dis. 2015 Apr 23;6(4):e1735. doi: 10.1038/cddis.2015.105. Cell Death Dis. 2015. PMID: 25906158 Free PMC article.

5

Physiological restraint of Bak by Bcl-xL is essential for cell survival.

Lee EF, Grabow S, Chappaz S, Dewson G, Hockings C, Kluck RM, Debrincat MA, Gray DH, Witkowski MT, Evangelista M, Pettikiriarachchi A, Bouillet P, Lane RM, Czabotar PE, Colman PM, Smith BJ, Kile BT, Fairlie WD. Lee EF, et al. Among authors: hockings c. Genes Dev. 2016 May 15;30(10):1240-50. doi: 10.1101/gad.279414.116. Epub 2016 May 19. Genes Dev. 2016. PMID: 27198225 Free PMC article.

6

BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove.

Li MX, Tan IKL, Ma SB, Hockings C, Kratina T, Dengler MA, Alsop AE, Kluck RM, Dewson G. Li MX, et al. Among authors: hockings c. Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7629-7634. doi: 10.1073/pnas.1702453114. Epub 2017 Jul 3. Proc Natl Acad Sci U S A. 2017. PMID: 28673969 Free PMC article.

7

Mcl-1 and Bcl-x_L sequestration of Bak confers differential resistance to BH3-only proteins.

Hockings C, Alsop AE, Fennell SC, Lee EF, Fairlie WD, Dewson G, Kluck RM. Hockings C, et al. Cell Death Differ. 2018 Mar;25(4):721-734. doi: 10.1038/s41418-017-0010-6. Epub 2018 Feb 19. Cell Death Differ. 2018. PMID: 29459767 Free PMC article.

8

VDAC2 enables BAX to mediate apoptosis and limit tumor development.

Chin HS, Li MX, Tan IKL, Ninnis RL, Reljic B, Scicluna K, Dagley LF, Sandow JJ, Kelly GL, Samson AL, Chappaz S, Khaw SL, Chang C, Morokoff A, Brinkmann K, Webb A, Hockings C, Hall CM, Kueh AJ, Ryan MT, Kluck RM, Bouillet P, Herold MJ, Gray DHD, Huang DCS, van Delft MF, Dewson G. Chin HS, et al. Among authors: hockings c. Nat Commun. 2018 Nov 26;9(1):4976. doi: 10.1038/s41467-018-07309-4. Nat Commun. 2018. PMID: 30478310 Free PMC article.

9

Avoiding adsorption of Bcl-2 proteins to plasticware is important for accurate quantitation.

Hockings C, Iyer S, Uren RT, Kluck RM. Hockings C, et al. Cell Death Differ. 2019 May;26(5):794-795. doi: 10.1038/s41418-019-0284-y. Epub 2019 Feb 13. Cell Death Differ. 2019. PMID: 30760874 Free PMC article. No abstract available.

10

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.

Linossi EM, Li K, Veggiani G, Tan C, Dehkhoda F, Hockings C, Calleja DJ, Keating N, Feltham R, Brooks AJ, Li SS, Sidhu SS, Babon JJ, Kershaw NJ, Nicholson SE. Linossi EM, et al. Among authors: hockings c. Nat Commun. 2021 Dec 2;12(1):7032. doi: 10.1038/s41467-021-26983-5. Nat Commun. 2021. PMID: 34857742 Free PMC article.

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