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A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients.
Higgs BW, Zhu W, Morehouse C, White WI, Brohawn P, Guo X, Rebelatto M, Le C, Amato A, Fiorentino D, Greenberg SA, Drappa J, Richman L, Greth W, Jallal B, Yao Y. Higgs BW, et al. Among authors: amato a. Ann Rheum Dis. 2014 Jan;73(1):256-62. doi: 10.1136/annrheumdis-2012-202794. Epub 2013 Feb 23. Ann Rheum Dis. 2014. PMID: 23434567 Free PMC article. Clinical Trial.
Interferon-alpha/beta-mediated innate immune mechanisms in dermatomyositis.
Greenberg SA, Pinkus JL, Pinkus GS, Burleson T, Sanoudou D, Tawil R, Barohn RJ, Saperstein DS, Briemberg HR, Ericsson M, Park P, Amato AA. Greenberg SA, et al. Among authors: amato aa. Ann Neurol. 2005 May;57(5):664-78. doi: 10.1002/ana.20464. Ann Neurol. 2005. PMID: 15852401
Immune-mediated necrotizing myopathy associated with statins.
Grable-Esposito P, Katzberg HD, Greenberg SA, Srinivasan J, Katz J, Amato AA. Grable-Esposito P, et al. Among authors: amato aa. Muscle Nerve. 2010 Feb;41(2):185-90. doi: 10.1002/mus.21486. Muscle Nerve. 2010. PMID: 19813188
1,523 results