Chiga M - Search Results

1

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.

Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Matsuo H, Murata T, Nomura S, Asano T, Kawaguchi H, Nonoyama S, Rai T, Sasaki S, Uchida S. Wakabayashi M, et al. Among authors: chiga m. Cell Rep. 2013 Mar 28;3(3):858-68. doi: 10.1016/j.celrep.2013.02.024. Epub 2013 Feb 28. Cell Rep. 2013. PMID: 23453970 Free article.

2

Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model.

Yang SS, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin SH, Moriguchi T, Shibuya H, Kondo Y, Sasaki S, Uchida S. Yang SS, et al. Among authors: chiga m. Cell Metab. 2007 May;5(5):331-44. doi: 10.1016/j.cmet.2007.03.009. Cell Metab. 2007. PMID: 17488636 Free article.

3

Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure.

Ohta A, Rai T, Yui N, Chiga M, Yang SS, Lin SH, Sohara E, Sasaki S, Uchida S. Ohta A, et al. Among authors: chiga m. Hum Mol Genet. 2009 Oct 15;18(20):3978-86. doi: 10.1093/hmg/ddp344. Epub 2009 Jul 24. Hum Mol Genet. 2009. PMID: 19633012

4

Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.

Chiga M, Rafiqi FH, Alessi DR, Sohara E, Ohta A, Rai T, Sasaki S, Uchida S. Chiga M, et al. J Cell Sci. 2011 May 1;124(Pt 9):1391-5. doi: 10.1242/jcs.084111. Epub 2011 Apr 12. J Cell Sci. 2011. PMID: 21486947

5

Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination.

Hossain Khan MZ, Sohara E, Ohta A, Chiga M, Inoue Y, Isobe K, Wakabayashi M, Oi K, Rai T, Sasaki S, Uchida S. Hossain Khan MZ, et al. Among authors: chiga m. Biochem Biophys Res Commun. 2012 Aug 24;425(2):456-61. doi: 10.1016/j.bbrc.2012.07.124. Epub 2012 Jul 27. Biochem Biophys Res Commun. 2012. PMID: 22846565

6

Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.

Susa K, Sohara E, Rai T, Zeniya M, Mori Y, Mori T, Chiga M, Nomura N, Nishida H, Takahashi D, Isobe K, Inoue Y, Takeishi K, Takeda N, Sasaki S, Uchida S. Susa K, et al. Among authors: chiga m. Hum Mol Genet. 2014 Oct 1;23(19):5052-60. doi: 10.1093/hmg/ddu217. Epub 2014 May 12. Hum Mol Genet. 2014. PMID: 24821705

7

Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3.

Yoshizaki Y, Mori Y, Tsuzaki Y, Mori T, Nomura N, Wakabayashi M, Takahashi D, Zeniya M, Kikuchi E, Araki Y, Ando F, Isobe K, Nishida H, Ohta A, Susa K, Inoue Y, Chiga M, Rai T, Sasaki S, Uchida S, Sohara E. Yoshizaki Y, et al. Among authors: chiga m. Biochem Biophys Res Commun. 2015 Nov 13;467(2):229-34. doi: 10.1016/j.bbrc.2015.09.184. Epub 2015 Oct 3. Biochem Biophys Res Commun. 2015. PMID: 26435498

8

WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice.

Takahashi D, Mori T, Sohara E, Tanaka M, Chiga M, Inoue Y, Nomura N, Zeniya M, Ochi H, Takeda S, Suganami T, Rai T, Uchida S. Takahashi D, et al. Among authors: chiga m. EBioMedicine. 2017 Apr;18:118-127. doi: 10.1016/j.ebiom.2017.03.011. Epub 2017 Mar 8. EBioMedicine. 2017. PMID: 28314693 Free PMC article.

9

Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells.

Ohta A, Yang SS, Rai T, Chiga M, Sasaki S, Uchida S. Ohta A, et al. Among authors: chiga m. Biochem Biophys Res Commun. 2006 Oct 20;349(2):804-8. doi: 10.1016/j.bbrc.2006.08.101. Epub 2006 Aug 24. Biochem Biophys Res Commun. 2006. PMID: 16949040

10

Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone.

Chiga M, Rai T, Yang SS, Ohta A, Takizawa T, Sasaki S, Uchida S. Chiga M, et al. Kidney Int. 2008 Dec;74(11):1403-9. doi: 10.1038/ki.2008.451. Epub 2008 Sep 17. Kidney Int. 2008. PMID: 18800028 Free article.

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