Frydman J - Search Results

1

Hsp90 inhibitors exhibit resistance-free antiviral activity against respiratory syncytial virus.

Geller R, Andino R, Frydman J. Geller R, et al. Among authors: frydman j. PLoS One. 2013;8(2):e56762. doi: 10.1371/journal.pone.0056762. Epub 2013 Feb 27. PLoS One. 2013. PMID: 23460813 Free PMC article.

2

The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions.

Tam S, Geller R, Spiess C, Frydman J. Tam S, et al. Among authors: frydman j. Nat Cell Biol. 2006 Oct;8(10):1155-62. doi: 10.1038/ncb1477. Epub 2006 Sep 17. Nat Cell Biol. 2006. PMID: 16980959 Free PMC article.

3

Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance.

Geller R, Vignuzzi M, Andino R, Frydman J. Geller R, et al. Among authors: frydman j. Genes Dev. 2007 Jan 15;21(2):195-205. doi: 10.1101/gad.1505307. Genes Dev. 2007. PMID: 17234885 Free PMC article.

4

Heterozygous yeast deletion collection screens reveal essential targets of Hsp90.

Franzosa EA, Albanèse V, Frydman J, Xia Y, McClellan AJ. Franzosa EA, et al. Among authors: frydman j. PLoS One. 2011;6(11):e28211. doi: 10.1371/journal.pone.0028211. Epub 2011 Nov 30. PLoS One. 2011. PMID: 22140548 Free PMC article.

5

Broad action of Hsp90 as a host chaperone required for viral replication.

Geller R, Taguwa S, Frydman J. Geller R, et al. Among authors: frydman j. Biochim Biophys Acta. 2012 Mar;1823(3):698-706. doi: 10.1016/j.bbamcr.2011.11.007. Epub 2011 Dec 2. Biochim Biophys Acta. 2012. PMID: 22154817 Free PMC article. Review.

6

The role of mutational robustness in RNA virus evolution.

Lauring AS, Frydman J, Andino R. Lauring AS, et al. Among authors: frydman j. Nat Rev Microbiol. 2013 May;11(5):327-36. doi: 10.1038/nrmicro3003. Epub 2013 Mar 25. Nat Rev Microbiol. 2013. PMID: 23524517 Free PMC article. Review.

7

Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection.

Taguwa S, Maringer K, Li X, Bernal-Rubio D, Rauch JN, Gestwicki JE, Andino R, Fernandez-Sesma A, Frydman J. Taguwa S, et al. Among authors: frydman j. Cell. 2015 Nov 19;163(5):1108-1123. doi: 10.1016/j.cell.2015.10.046. Epub 2015 Nov 12. Cell. 2015. PMID: 26582131 Free PMC article.

8

Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation.

Geller R, Pechmann S, Acevedo A, Andino R, Frydman J. Geller R, et al. Among authors: frydman j. Nat Commun. 2018 May 3;9(1):1781. doi: 10.1038/s41467-018-04203-x. Nat Commun. 2018. PMID: 29725062 Free PMC article.

9

A Viral Protein Restricts Drosophila RNAi Immunity by Regulating Argonaute Activity and Stability.

Nayak A, Kim DY, Trnka MJ, Kerr CH, Lidsky PV, Stanley DJ, Rivera BM, Li KH, Burlingame AL, Jan E, Frydman J, Gross JD, Andino R. Nayak A, et al. Among authors: frydman j. Cell Host Microbe. 2018 Oct 10;24(4):542-557.e9. doi: 10.1016/j.chom.2018.09.006. Cell Host Microbe. 2018. PMID: 30308158 Free PMC article.

10

Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease.

Taguwa S, Yeh MT, Rainbolt TK, Nayak A, Shao H, Gestwicki JE, Andino R, Frydman J. Taguwa S, et al. Among authors: frydman j. Cell Rep. 2019 Jan 22;26(4):906-920.e3. doi: 10.1016/j.celrep.2018.12.095. Cell Rep. 2019. PMID: 30673613 Free PMC article.

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