Cortés-Ledesma F - Search Results

1

TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.

Gómez-Herreros F, Romero-Granados R, Zeng Z, Alvarez-Quilón A, Quintero C, Ju L, Umans L, Vermeire L, Huylebroeck D, Caldecott KW, Cortés-Ledesma F. Gómez-Herreros F, et al. PLoS Genet. 2013;9(3):e1003226. doi: 10.1371/journal.pgen.1003226. Epub 2013 Mar 7. PLoS Genet. 2013. PMID: 23505375 Free PMC article.

2

APLF (C2orf13) is a novel component of poly(ADP-ribose) signaling in mammalian cells.

Rulten SL, Cortes-Ledesma F, Guo L, Iles NJ, Caldecott KW. Rulten SL, et al. Mol Cell Biol. 2008 Jul;28(14):4620-8. doi: 10.1128/MCB.02243-07. Epub 2008 May 12. Mol Cell Biol. 2008. PMID: 18474613 Free PMC article.

3

A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage.

Cortes Ledesma F, El Khamisy SF, Zuma MC, Osborn K, Caldecott KW. Cortes Ledesma F, et al. Nature. 2009 Oct 1;461(7264):674-8. doi: 10.1038/nature08444. Nature. 2009. PMID: 19794497

4

TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.

Zeng Z, Cortés-Ledesma F, El Khamisy SF, Caldecott KW. Zeng Z, et al. J Biol Chem. 2011 Jan 7;286(1):403-9. doi: 10.1074/jbc.M110.181016. Epub 2010 Oct 28. J Biol Chem. 2011. PMID: 21030584 Free PMC article.

5

ATM specifically mediates repair of double-strand breaks with blocked DNA ends.

Álvarez-Quilón A, Serrano-Benítez A, Lieberman JA, Quintero C, Sánchez-Gutiérrez D, Escudero LM, Cortés-Ledesma F. Álvarez-Quilón A, et al. Nat Commun. 2014 Feb 27;5:3347. doi: 10.1038/ncomms4347. Nat Commun. 2014. PMID: 24572510 Free PMC article.

6

TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.

Gómez-Herreros F, Schuurs-Hoeijmakers JH, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, Chaila E, Conroy J, Ennis S, Delanty N, Cortés-Ledesma F, de Brouwer AP, Cavalleri GL, El-Khamisy SF, de Vries BB, Caldecott KW. Gómez-Herreros F, et al. Nat Genet. 2014 May;46(5):516-21. doi: 10.1038/ng.2929. Epub 2014 Mar 23. Nat Genet. 2014. PMID: 24658003

7

Does Tyrosyl DNA Phosphodiesterase-2 Play a Role in Hepatitis B Virus Genome Repair?

Cui X, McAllister R, Boregowda R, Sohn JA, Cortes Ledesma F, Caldecott KW, Seeger C, Hu J. Cui X, et al. PLoS One. 2015 Jun 16;10(6):e0128401. doi: 10.1371/journal.pone.0128401. eCollection 2015. PLoS One. 2015. PMID: 26079492 Free PMC article.

8

Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks.

Caron P, Choudjaye J, Clouaire T, Bugler B, Daburon V, Aguirrebengoa M, Mangeat T, Iacovoni JS, Álvarez-Quilón A, Cortés-Ledesma F, Legube G. Caron P, et al. Cell Rep. 2015 Nov 24;13(8):1598-609. doi: 10.1016/j.celrep.2015.10.024. Epub 2015 Nov 12. Cell Rep. 2015. PMID: 26586426 Free PMC article.

9

Divergent Requirement for a DNA Repair Enzyme during Enterovirus Infections.

Maciejewski S, Nguyen JH, Gómez-Herreros F, Cortés-Ledesma F, Caldecott KW, Semler BL. Maciejewski S, et al. mBio. 2015 Dec 29;7(1):e01931-15. doi: 10.1128/mBio.01931-15. mBio. 2015. PMID: 26715620 Free PMC article.

10

Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency.

Álvarez-Quilón A, Terrón-Bautista J, Delgado-Sainz I, Serrano-Benítez A, Romero-Granados R, Martínez-García PM, Jimeno-González S, Bernal-Lozano C, Quintero C, García-Quintanilla L, Cortés-Ledesma F. Álvarez-Quilón A, et al. Nat Commun. 2020 Feb 14;11(1):910. doi: 10.1038/s41467-020-14638-w. Nat Commun. 2020. PMID: 32060399 Free PMC article.

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