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Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.
Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H. Wang X, et al. Among authors: zhou y. Nat Med. 2013 Apr;19(4):473-80. doi: 10.1038/nm.3117. Epub 2013 Mar 24. Nat Med. 2013. PMID: 23524343 Free PMC article.
The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability.
Zeng F, Ma X, Zhu L, Xu Q, Zeng Y, Gao Y, Li G, Guo T, Zhang H, Tang X, Wang Z, Ye Z, Zheng L, Zhang H, Zheng Q, Li K, Lu J, Qi X, Luo H, Zhang X, Wang Z, Zhou Y, Yao Y, Ke R, Zhou Y, Liu Y, Sun H, Huang T, Shao Z, Xu H, Wang X. Zeng F, et al. Among authors: zhou y. PLoS Biol. 2019 Dec 16;17(12):e3000525. doi: 10.1371/journal.pbio.3000525. eCollection 2019 Dec. PLoS Biol. 2019. PMID: 31841517 Free PMC article.
SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate.
Zhang H, Hong Y, Yang W, Wang R, Yao T, Wang J, Liu K, Yuan H, Xu C, Zhou Y, Li G, Zhang L, Luo H, Zhang X, Du D, Sun H, Zheng Q, Zhang YW, Zhao Y, Zhou Y, Xu H, Wang X. Zhang H, et al. Among authors: zhou y. Natl Sci Rev. 2021 Feb 10;8(7):nwab024. doi: 10.1093/nsr/nwab024. eCollection 2021 Jul. Natl Sci Rev. 2021. PMID: 34691693 Free PMC article.
USP25 inhibition ameliorates Alzheimer's pathology through the regulation of APP processing and Aβ generation.
Zheng Q, Song B, Li G, Cai F, Wu M, Zhao Y, Jiang L, Guo T, Shen M, Hou H, Zhou Y, Zhao Y, Di A, Zhang L, Zeng F, Zhang XF, Luo H, Zhang X, Zhang H, Zeng Z, Huang TY, Dong C, Qing H, Zhang Y, Zhang Q, Wang X, Wu Y, Xu H, Song W, Wang X. Zheng Q, et al. Among authors: zhou y. J Clin Invest. 2022 Mar 1;132(5):e152170. doi: 10.1172/JCI152170. J Clin Invest. 2022. PMID: 35229730 Free PMC article.
Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability.
Zhang H, Zheng Q, Guo T, Zhang S, Zheng S, Wang R, Deng Q, Yang G, Zhang S, Tang L, Qi Q, Zhu L, Zhang XF, Luo H, Zhang X, Sun H, Gao Y, Zhang H, Zhou Y, Han A, Zhang CS, Xu H, Wang X. Zhang H, et al. Among authors: zhou y. Mol Psychiatry. 2024 Jun;29(6):1569-1582. doi: 10.1038/s41380-022-01521-x. Epub 2022 Mar 25. Mol Psychiatry. 2024. PMID: 35338313
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