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Ligand-binding dynamics rewire cellular signaling via estrogen receptor-α.
Srinivasan S, Nwachukwu JC, Parent AA, Cavett V, Nowak J, Hughes TS, Kojetin DJ, Katzenellenbogen JA, Nettles KW. Srinivasan S, et al. Among authors: katzenellenbogen ja. Nat Chem Biol. 2013 May;9(5):326-32. doi: 10.1038/nchembio.1214. Epub 2013 Mar 24. Nat Chem Biol. 2013. PMID: 23524984 Free PMC article.
Estrogen receptor microarrays: subtype-selective ligand binding.
Kim SH, Tamrazi A, Carlson KE, Daniels JR, Lee IY, Katzenellenbogen JA. Kim SH, et al. Among authors: katzenellenbogen ja. J Am Chem Soc. 2004 Apr 21;126(15):4754-5. doi: 10.1021/ja039586q. J Am Chem Soc. 2004. PMID: 15080660
Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands.
Zhou HB, Nettles KW, Bruning JB, Kim Y, Joachimiak A, Sharma S, Carlson KE, Stossi F, Katzenellenbogen BS, Greene GL, Katzenellenbogen JA. Zhou HB, et al. Among authors: katzenellenbogen bs, katzenellenbogen ja. Chem Biol. 2007 Jun;14(6):659-69. doi: 10.1016/j.chembiol.2007.04.009. Chem Biol. 2007. PMID: 17584613
NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses.
Nettles KW, Bruning JB, Gil G, Nowak J, Sharma SK, Hahm JB, Kulp K, Hochberg RB, Zhou H, Katzenellenbogen JA, Katzenellenbogen BS, Kim Y, Joachmiak A, Greene GL. Nettles KW, et al. Among authors: katzenellenbogen bs, katzenellenbogen ja. Nat Chem Biol. 2008 Apr;4(4):241-7. doi: 10.1038/nchembio.76. Epub 2008 Mar 16. Nat Chem Biol. 2008. PMID: 18344977 Free PMC article.
Coupling of receptor conformation and ligand orientation determine graded activity.
Bruning JB, Parent AA, Gil G, Zhao M, Nowak J, Pace MC, Smith CL, Afonine PV, Adams PD, Katzenellenbogen JA, Nettles KW. Bruning JB, et al. Among authors: katzenellenbogen ja. Nat Chem Biol. 2010 Nov;6(11):837-43. doi: 10.1038/nchembio.451. Epub 2010 Oct 10. Nat Chem Biol. 2010. PMID: 20924370 Free PMC article.
Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: defining the binding mode of 7-oxabicyclo[2.2.1]hept-5-ene scaffold core ligands.
Zheng Y, Zhu M, Srinivasan S, Nwachukwu JC, Cavett V, Min J, Carlson KE, Wang P, Dong C, Katzenellenbogen JA, Nettles KW, Zhou HB. Zheng Y, et al. Among authors: katzenellenbogen ja. ChemMedChem. 2012 Jun;7(6):1094-100. doi: 10.1002/cmdc.201200048. Epub 2012 Apr 19. ChemMedChem. 2012. PMID: 22517684 Free PMC article.
516 results