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Ligand-binding dynamics rewire cellular signaling via estrogen receptor-α.
Srinivasan S, Nwachukwu JC, Parent AA, Cavett V, Nowak J, Hughes TS, Kojetin DJ, Katzenellenbogen JA, Nettles KW. Srinivasan S, et al. Among authors: nettles kw. Nat Chem Biol. 2013 May;9(5):326-32. doi: 10.1038/nchembio.1214. Epub 2013 Mar 24. Nat Chem Biol. 2013. PMID: 23524984 Free PMC article.
Structural plasticity in the oestrogen receptor ligand-binding domain.
Nettles KW, Bruning JB, Gil G, O'Neill EE, Nowak J, Guo Y, Kim Y, DeSombre ER, Dilis R, Hanson RN, Joachimiak A, Greene GL. Nettles KW, et al. EMBO Rep. 2007 Jun;8(6):563-8. doi: 10.1038/sj.embor.7400963. Epub 2007 Apr 27. EMBO Rep. 2007. PMID: 17468738 Free PMC article.
Coupling of receptor conformation and ligand orientation determine graded activity.
Bruning JB, Parent AA, Gil G, Zhao M, Nowak J, Pace MC, Smith CL, Afonine PV, Adams PD, Katzenellenbogen JA, Nettles KW. Bruning JB, et al. Among authors: nettles kw. Nat Chem Biol. 2010 Nov;6(11):837-43. doi: 10.1038/nchembio.451. Epub 2010 Oct 10. Nat Chem Biol. 2010. PMID: 20924370 Free PMC article.
62 results