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β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons.
Taschenberger G, Toloe J, Tereshchenko J, Akerboom J, Wales P, Benz R, Becker S, Outeiro TF, Looger LL, Bähr M, Zweckstetter M, Kügler S. Taschenberger G, et al. Among authors: benz r. Ann Neurol. 2013 Jul;74(1):109-18. doi: 10.1002/ana.23905. Epub 2013 Aug 6. Ann Neurol. 2013. PMID: 23536356
Structural properties of pore-forming oligomers of alpha-synuclein.
Kim HY, Cho MK, Kumar A, Maier E, Siebenhaar C, Becker S, Fernandez CO, Lashuel HA, Benz R, Lange A, Zweckstetter M. Kim HY, et al. Among authors: benz r. J Am Chem Soc. 2009 Dec 2;131(47):17482-9. doi: 10.1021/ja9077599. J Am Chem Soc. 2009. PMID: 19888725 Free article.
β-Barrel mobility underlies closure of the voltage-dependent anion channel.
Zachariae U, Schneider R, Briones R, Gattin Z, Demers JP, Giller K, Maier E, Zweckstetter M, Griesinger C, Becker S, Benz R, de Groot BL, Lange A. Zachariae U, et al. Among authors: benz r. Structure. 2012 Sep 5;20(9):1540-9. doi: 10.1016/j.str.2012.06.015. Epub 2012 Jul 26. Structure. 2012. PMID: 22841291 Free PMC article.
The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.
Martinez Hernandez A, Urbanke H, Gillman AL, Lee J, Ryazanov S, Agbemenyah HY, Benito E, Jain G, Kaurani L, Grigorian G, Leonov A, Rezaei-Ghaleh N, Wilken P, Arce FT, Wagner J, Fuhrmann M, Caruana M, Camilleri A, Vassallo N, Zweckstetter M, Benz R, Giese A, Schneider A, Korte M, Lal R, Griesinger C, Eichele G, Fischer A. Martinez Hernandez A, et al. Among authors: benz r. EMBO Mol Med. 2018 Jan;10(1):32-47. doi: 10.15252/emmm.201707825. EMBO Mol Med. 2018. PMID: 29208638 Free PMC article.
635 results