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Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells.
Martinelli E, Troiani T, D'Aiuto E, Morgillo F, Vitagliano D, Capasso A, Costantino S, Ciuffreda LP, Merolla F, Vecchione L, De Vriendt V, Tejpar S, Nappi A, Sforza V, Martini G, Berrino L, De Palma R, Ciardiello F. Martinelli E, et al. Among authors: tejpar s. Int J Cancer. 2013 Nov;133(9):2089-101. doi: 10.1002/ijc.28236. Epub 2013 May 29. Int J Cancer. 2013. PMID: 23629727
EGFR-targeted therapy.
Vecchione L, Jacobs B, Normanno N, Ciardiello F, Tejpar S. Vecchione L, et al. Among authors: tejpar s. Exp Cell Res. 2011 Nov 15;317(19):2765-71. doi: 10.1016/j.yexcr.2011.08.021. Epub 2011 Sep 7. Exp Cell Res. 2011. PMID: 21925171 Review.
Targeted therapies: how personal should we go?
Martini M, Vecchione L, Siena S, Tejpar S, Bardelli A. Martini M, et al. Among authors: tejpar s. Nat Rev Clin Oncol. 2011 Nov 15;9(2):87-97. doi: 10.1038/nrclinonc.2011.164. Nat Rev Clin Oncol. 2011. PMID: 22083042 Review.
Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells.
Troiani T, Vecchione L, Martinelli E, Capasso A, Costantino S, Ciuffreda LP, Morgillo F, Vitagliano D, D'Aiuto E, De Palma R, Tejpar S, Van Cutsem E, De Lorenzi M, Caraglia M, Berrino L, Ciardiello F. Troiani T, et al. Among authors: tejpar s. Br J Cancer. 2012 May 8;106(10):1648-59. doi: 10.1038/bjc.2012.129. Br J Cancer. 2012. PMID: 22569000 Free PMC article.
KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy.
Valtorta E, Misale S, Sartore-Bianchi A, Nagtegaal ID, Paraf F, Lauricella C, Dimartino V, Hobor S, Jacobs B, Ercolani C, Lamba S, Scala E, Veronese S, Laurent-Puig P, Siena S, Tejpar S, Mottolese M, Punt CJ, Gambacorta M, Bardelli A, Di Nicolantonio F. Valtorta E, et al. Among authors: tejpar s. Int J Cancer. 2013 Sep 1;133(5):1259-65. doi: 10.1002/ijc.28106. Epub 2013 Mar 16. Int J Cancer. 2013. PMID: 23404247 Free article.
255 results