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Page 1
An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour.
Motamedi-Shad N, Jagger AM, Liedtke M, Faull SV, Nanda AS, Salvadori E, Wort JL, Kay CW, Heyer-Chauhan N, Miranda E, Perez J, Ordóñez A, Haq I, Irving JA, Lomas DA. Motamedi-Shad N, et al. Among authors: faull sv. Biochem J. 2016 Oct 1;473(19):3269-90. doi: 10.1042/BCJ20160159. Epub 2016 Jul 12. Biochem J. 2016. PMID: 27407165 Free PMC article.
The structural basis for Z α1-antitrypsin polymerization in the liver.
Faull SV, Elliston ELK, Gooptu B, Jagger AM, Aldobiyan I, Redzej A, Badaoui M, Heyer-Chauhan N, Rashid ST, Reynolds GM, Adams DH, Miranda E, Orlova EV, Irving JA, Lomas DA. Faull SV, et al. Sci Adv. 2020 Oct 21;6(43):eabc1370. doi: 10.1126/sciadv.abc1370. Print 2020 Oct. Sci Adv. 2020. PMID: 33087346 Free PMC article.