Lomas DA - Search Results

1

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway.

Haq I, Irving JA, Faull SV, Dickens JA, Ordóñez A, Belorgey D, Gooptu B, Lomas DA. Haq I, et al. Among authors: lomas da. Biosci Rep. 2013 Jun 25;33(3):e00046. doi: 10.1042/BSR20130038. Biosci Rep. 2013. PMID: 23659468 Free PMC article.

2

6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis.

Mahadeva R, Dafforn TR, Carrell RW, Lomas DA. Mahadeva R, et al. Among authors: lomas da. J Biol Chem. 2002 Mar 1;277(9):6771-4. doi: 10.1074/jbc.C100722200. Epub 2001 Dec 28. J Biol Chem. 2002. PMID: 11773044 Free article.

3

Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro.

Belorgey D, Crowther DC, Mahadeva R, Lomas DA. Belorgey D, et al. Among authors: lomas da. J Biol Chem. 2002 May 10;277(19):17367-73. doi: 10.1074/jbc.M200680200. Epub 2002 Mar 5. J Biol Chem. 2002. PMID: 11880376 Free article.

4

Characterization of the necrotic protein that regulates the Toll-mediated immune response in Drosophila.

Robertson AS, Belorgey D, Lilley KS, Lomas DA, Gubb D, Dafforn TR. Robertson AS, et al. Among authors: lomas da. J Biol Chem. 2003 Feb 21;278(8):6175-80. doi: 10.1074/jbc.M209277200. Epub 2002 Oct 31. J Biol Chem. 2003. PMID: 12414799 Free article.

5

Nucleation of alpha 1-antichymotrypsin polymerization.

Crowther DC, Serpell LC, Dafforn TR, Gooptu B, Lomas DA. Crowther DC, et al. Among authors: lomas da. Biochemistry. 2003 Mar 4;42(8):2355-63. doi: 10.1021/bi0259305. Biochemistry. 2003. PMID: 12600202

6

Alpha(1)-antitrypsin deficiency, liver disease and emphysema.

Parfrey H, Mahadeva R, Lomas DA. Parfrey H, et al. Among authors: lomas da. Int J Biochem Cell Biol. 2003 Jul;35(7):1009-14. doi: 10.1016/s1357-2725(02)00250-9. Int J Biochem Cell Biol. 2003. PMID: 12672469 Review.

7

Targeting a surface cavity of alpha 1-antitrypsin to prevent conformational disease.

Parfrey H, Mahadeva R, Ravenhill NA, Zhou A, Dafforn TR, Foreman RC, Lomas DA. Parfrey H, et al. Among authors: lomas da. J Biol Chem. 2003 Aug 29;278(35):33060-6. doi: 10.1074/jbc.M302646200. Epub 2003 Jun 13. J Biol Chem. 2003. PMID: 12807889 Free article.

8

Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies.

Crowther DC, Belorgey D, Miranda E, Kinghorn KJ, Sharp LK, Lomas DA. Crowther DC, et al. Among authors: lomas da. Eur J Hum Genet. 2004 Mar;12(3):167-72. doi: 10.1038/sj.ejhg.5201127. Eur J Hum Genet. 2004. PMID: 14694355 Review.

9

Inhibiting polymerization: new therapeutic strategies for Z alpha1-antitrypsin-related emphysema.

Parfrey H, Dafforn TR, Belorgey D, Lomas DA, Mahadeva R. Parfrey H, et al. Among authors: lomas da. Am J Respir Cell Mol Biol. 2004 Aug;31(2):133-9. doi: 10.1165/rcmb.2003-0276OC. Epub 2004 Mar 11. Am J Respir Cell Mol Biol. 2004. PMID: 15016619

10

Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB.

Belorgey D, Sharp LK, Crowther DC, Onda M, Johansson J, Lomas DA. Belorgey D, et al. Among authors: lomas da. Eur J Biochem. 2004 Aug;271(16):3360-7. doi: 10.1111/j.1432-1033.2004.04270.x. Eur J Biochem. 2004. PMID: 15291813 Free article.

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