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Page 1
In antibody-positive first-degree relatives of patients with type 1 diabetes, HLA-A*24 and HLA-B*18, but not HLA-B*39, are predictors of impending diabetes with distinct HLA-DQ interactions.
Mbunwe E, Van der Auwera BJ, Weets I, Van Crombrugge P, Crenier L, Coeckelberghs M, Seret N, Decochez K, Vandemeulebroucke E, Gillard P, Keymeulen B, van Schravendijk C, Wenzlau JM, Hutton JC, Pipeleers DG, Gorus FK; Belgian Diabetes Registry. Mbunwe E, et al. Among authors: van der auwera bj. Diabetologia. 2013 Sep;56(9):1964-70. doi: 10.1007/s00125-013-2951-8. Epub 2013 May 28. Diabetologia. 2013. PMID: 23712485 Free PMC article.
Relation between disease phenotype and HLA-DQ genotype in diabetic patients diagnosed in early adulthood.
Weets I, Siraux V, Daubresse JC, De Leeuw IH, Féry F, Keymeulen B, Krzentowski G, Letiexhe M, Mathieu C, Nobels F, Rottiers R, Scheen A, Van Gaal L, Schuit FC, Van der Auwera B, Rui M, De Pauw P, Kaufman L, Gorus FK; Belgian Diabetes Registry. Weets I, et al. J Clin Endocrinol Metab. 2002 Jun;87(6):2597-605. doi: 10.1210/jcem.87.6.8613. J Clin Endocrinol Metab. 2002. PMID: 12050221 Free article.
Accelerated Progression to Type 1 Diabetes in the Presence of HLA-A*24 and -B*18 Is Restricted to Multiple Islet Autoantibody-Positive Individuals With Distinct HLA-DQ and Autoantibody Risk Profiles.
Balke EM, Balti EV, Van der Auwera B, Weets I, Costa O, Demeester S, Abrams P, Casteels K, Coeckelberghs M, Tenoutasse S, Keymeulen B, Pipeleers DG, Gorus FK; Belgian Diabetes Registry. Balke EM, et al. Diabetes Care. 2018 May;41(5):1076-1083. doi: 10.2337/dc17-2462. Epub 2018 Mar 15. Diabetes Care. 2018. PMID: 29545461
Genetic variation at ERBB3/IKZF4 and sexual dimorphism in epitope spreading in single autoantibody-positive relatives.
Vandewalle J, Van der Auwera BJ, Amin H, Quartier E, Desouter AK, Tenoutasse S, Gillard P, De Block C, Keymeulen B, Gorus FK, Van de Casteele M; Belgian Diabetes Registry. Vandewalle J, et al. Among authors: van der auwera bj. Diabetologia. 2021 Nov;64(11):2511-2516. doi: 10.1007/s00125-021-05546-9. Epub 2021 Aug 26. Diabetologia. 2021. PMID: 34448034 Free PMC article.
HLA-A*24 is an independent predictor of 5-year progression to diabetes in autoantibody-positive first-degree relatives of type 1 diabetic patients.
Mbunwe E, Van der Auwera BJ, Vermeulen I, Demeester S, Van Dalem A, Balti EV, Van Aken S, Derdelinckx L, Dorchy H, De Schepper J, van Schravendijk C, Wenzlau JM, Hutton JC, Pipeleers D, Weets I, Gorus FK; Belgian Diabetes Registry. Mbunwe E, et al. Among authors: van der auwera bj. Diabetes. 2013 Apr;62(4):1345-50. doi: 10.2337/db12-0747. Epub 2012 Nov 16. Diabetes. 2013. PMID: 23160529 Free PMC article.
Male-to-female excess in diabetes diagnosed in early adulthood is not specific for the immune-mediated form nor is it HLA-DQ restricted: possible relation to increased body mass index.
Weets I, Van Autreve J, Van der Auwera BJ, Schuit FC, Du Caju MV, Decochez K, De Leeuw IH, Keymeulen B, Mathieu C, Rottiers R, Dorchy H, Quartier E, Gorus FK; Belgian Diabetes Registry. Weets I, et al. Among authors: van der auwera bj, van autreve j. Diabetologia. 2001 Jan;44(1):40-7. doi: 10.1007/s001250051578. Diabetologia. 2001. PMID: 11206410
Seasonality in clinical onset of type 1 diabetes in belgian patients above the age of 10 is restricted to HLA-DQ2/DQ8-negative males, which explains the male to female excess in incidence.
Weets I, Kaufman L, Van der Auwera B, Crenier L, Rooman RP, De Block C, Casteels K, Weber E, Coeckelberghs M, Laron Z, Pipeleers DG, Gorus FK; Belgian Diabetes Registry. Weets I, et al. Diabetologia. 2004 Apr;47(4):614-21. doi: 10.1007/s00125-004-1369-8. Diabetologia. 2004. PMID: 15298337
63 results