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Brain penetration, target engagement, and disposition of the blood-brain barrier-crossing bispecific antibody antagonist of metabotropic glutamate receptor type 1.
Webster CI, Caram-Salas N, Haqqani AS, Thom G, Brown L, Rennie K, Yogi A, Costain W, Brunette E, Stanimirovic DB. Webster CI, et al. Among authors: thom g. FASEB J. 2016 May;30(5):1927-40. doi: 10.1096/fj.201500078. Epub 2016 Feb 2. FASEB J. 2016. PMID: 26839377
We demonstrate the feasibility of targeting central G-protein-coupled receptors using a BBB-crossing bispecific antibody approach and emerging principles that govern brain distribution and disposition of these antibodies. ...-Webster, C. I., Caram-Salas, N., Haqqani, A. S. …
We demonstrate the feasibility of targeting central G-protein-coupled receptors using a BBB-crossing bispecific antibody approach and …
A variant human IgG1-Fc mediates improved ADCC.
Stewart R, Thom G, Levens M, Güler-Gane G, Holgate R, Rudd PM, Webster C, Jermutus L, Lund J. Stewart R, et al. Among authors: thom g. Protein Eng Des Sel. 2011 Sep;24(9):671-8. doi: 10.1093/protein/gzr015. Epub 2011 May 18. Protein Eng Des Sel. 2011. PMID: 21596686
A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model.
Thom G, Tian MM, Hatcher JP, Rodrigo N, Burrell M, Gurrell I, Vitalis TZ, Abraham T, Jefferies WA, Webster CI, Gabathuler R. Thom G, et al. J Cereb Blood Flow Metab. 2019 Oct;39(10):2074-2088. doi: 10.1177/0271678X18772998. Epub 2018 May 30. J Cereb Blood Flow Metab. 2019. PMID: 29845881 Free PMC article.
Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain.
Williams WA, Linley JE, Jones CA, Shibata Y, Snijder A, Button J, Hatcher JP, Huang L, Taddese B, Thornton P, Schofield DJ, Thom G, Popovic B, Dosanjh B, Wilkinson T, Hughes J, Dobson CL, Groves MA, Webster CI, Billinton A, Vaughan TJ, Chessell I. Williams WA, et al. Among authors: thom g. Pain. 2019 Sep;160(9):1989-2003. doi: 10.1097/j.pain.0000000000001587. Pain. 2019. PMID: 31045747
Probing a protein-protein interaction by in vitro evolution.
Thom G, Cockroft AC, Buchanan AG, Candotti CJ, Cohen ES, Lowne D, Monk P, Shorrock-Hart CP, Jermutus L, Minter RR. Thom G, et al. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7619-24. doi: 10.1073/pnas.0602341103. Epub 2006 May 9. Proc Natl Acad Sci U S A. 2006. PMID: 16684878 Free PMC article.
99 results