Thompson PE - Search Results

1

L-Aminoacyl-triazine derivatives are isoform-selective PI3Kβ inhibitors that target non-conserved Asp862 of PI3Kβ.

Pinson JA, Zheng Z, Miller MS, Chalmers DK, Jennings IG, Thompson PE. Pinson JA, et al. Among authors: thompson pe. ACS Med Chem Lett. 2013 Feb 14;4(2):206-210. doi: 10.1021/ml300336j. ACS Med Chem Lett. 2013. PMID: 23795239 Free PMC article.

2

Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket.

Frazzetto M, Suphioglu C, Zhu J, Schmidt-Kittler O, Jennings IG, Cranmer SL, Jackson SP, Kinzler KW, Vogelstein B, Thompson PE. Frazzetto M, et al. Among authors: thompson pe. Biochem J. 2008 Sep 15;414(3):383-90. doi: 10.1042/BJ20080512. Biochem J. 2008. PMID: 18489260 Free PMC article.

3

Inflammatory twins from PI3K gang brought to justice?

Thompson PE, Jennings IG, Pinson JA. Thompson PE, et al. Chem Biol. 2010 Feb 26;17(2):101-2. doi: 10.1016/j.chembiol.2010.02.001. Chem Biol. 2010. PMID: 20189098

4

Thiazolidinedione-based PI3Kα inhibitors: an analysis of biochemical and virtual screening methods.

Pinson JA, Schmidt-Kittler O, Zhu J, Jennings IG, Kinzler KW, Vogelstein B, Chalmers DK, Thompson PE. Pinson JA, et al. Among authors: thompson pe. ChemMedChem. 2011 Mar 7;6(3):514-22. doi: 10.1002/cmdc.201000467. Epub 2011 Jan 4. ChemMedChem. 2011. PMID: 21360822 Free PMC article.

5

Isoform-selective inhibition of phosphoinositide 3-kinase: identification of a new region of nonconserved amino acids critical for p110α inhibition.

Zheng Z, Amran SI, Thompson PE, Jennings IG. Zheng Z, et al. Among authors: thompson pe. Mol Pharmacol. 2011 Oct;80(4):657-64. doi: 10.1124/mol.111.072546. Epub 2011 Jul 21. Mol Pharmacol. 2011. PMID: 21778304

6

Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2.

Nankervis JL, Feil SC, Hancock NC, Zheng Z, Ng HL, Morton CJ, Holien JK, Ho PW, Frazzetto MM, Jennings IG, Manallack DT, Martin TJ, Thompson PE, Parker MW. Nankervis JL, et al. Among authors: thompson pe. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7089-93. doi: 10.1016/j.bmcl.2011.09.109. Epub 2011 Oct 5. Bioorg Med Chem Lett. 2011. PMID: 22030030

7

Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis.

Zheng Z, Amran SI, Zhu J, Schmidt-Kittler O, Kinzler KW, Vogelstein B, Shepherd PR, Thompson PE, Jennings IG. Zheng Z, et al. Among authors: thompson pe. Biochem J. 2012 Jun 15;444(3):529-35. doi: 10.1042/BJ20120499. Biochem J. 2012. PMID: 22502592 Free PMC article.

8

Regioselective synthesis of 5- and 6-methoxybenzimidazole-1,3,5-triazines as inhibitors of phosphoinositide 3-kinase.

Miller MS, Pinson JA, Zheng Z, Jennings IG, Thompson PE. Miller MS, et al. Among authors: thompson pe. Bioorg Med Chem Lett. 2013 Feb 1;23(3):802-5. doi: 10.1016/j.bmcl.2012.11.076. Epub 2012 Dec 1. Bioorg Med Chem Lett. 2013. PMID: 23265896

9

Mechanisms of PI3Kβ-selective inhibition revealed by reciprocal mutagenesis.

Zheng Z, Miller MS, Jennings IG, Thompson PE. Zheng Z, et al. Among authors: thompson pe. ACS Chem Biol. 2013 Apr 19;8(4):679-83. doi: 10.1021/cb300666s. Epub 2013 Feb 6. ACS Chem Biol. 2013. PMID: 23360067

10

(+)-Fluorenylethylchloroformate (FLEC)--improved synthesis for application in chiral analysis and peptidomimetic synthesis.

Camerino MA, Chalmers DK, Thompson PE. Camerino MA, et al. Among authors: thompson pe. Org Biomol Chem. 2013 Apr 28;11(16):2571-3. doi: 10.1039/c3ob40218e. Org Biomol Chem. 2013. PMID: 23483118

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

256 results

Search Page

Filters