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Genetics and cardiac channelopathies.
Campuzano O, Beltrán-Alvarez P, Iglesias A, Scornik F, Pérez G, Brugada R. Campuzano O, et al. Genet Med. 2010 May;12(5):260-7. doi: 10.1097/GIM.0b013e3181d81636. Genet Med. 2010. PMID: 20386317 Free article. Review.
A novel missense mutation, I890T, in the pore region of cardiac sodium channel causes Brugada syndrome.
Tarradas A, Selga E, Beltran-Alvarez P, Pérez-Serra A, Riuró H, Picó F, Iglesias A, Campuzano O, Castro-Urda V, Fernández-Lozano I, Pérez GJ, Scornik FS, Brugada R. Tarradas A, et al. Among authors: perez gj, perez serra a. PLoS One. 2013;8(1):e53220. doi: 10.1371/journal.pone.0053220. Epub 2013 Jan 7. PLoS One. 2013. PMID: 23308164 Free PMC article.
DiBAC₄(3) hits a "sweet spot" for the activation of arterial large-conductance Ca²⁺-activated potassium channels independently of the β₁-subunit.
Scornik FS, Bucciero RS, Wu Y, Selga E, Bosch Calero C, Brugada R, Pérez GJ. Scornik FS, et al. Among authors: perez gj. Am J Physiol Heart Circ Physiol. 2013 Jun 1;304(11):H1471-82. doi: 10.1152/ajpheart.00939.2012. Epub 2013 Mar 29. Am J Physiol Heart Circ Physiol. 2013. PMID: 23542916 Free PMC article.
Protein arginine methyl transferases-3 and -5 increase cell surface expression of cardiac sodium channel.
Beltran-Alvarez P, Espejo A, Schmauder R, Beltran C, Mrowka R, Linke T, Batlle M, Pérez-Villa F, Pérez GJ, Scornik FS, Benndorf K, Pagans S, Zimmer T, Brugada R. Beltran-Alvarez P, et al. Among authors: perez gj, perez villa f. FEBS Lett. 2013 Oct 1;587(19):3159-65. doi: 10.1016/j.febslet.2013.07.043. Epub 2013 Jul 31. FEBS Lett. 2013. PMID: 23912080 Free article.
47 results