Wielders SJ - Search Results

1

Factor Xa activation of factor V is of paramount importance in initiating the coagulation system: lessons from a tick salivary protein.

Schuijt TJ, Bakhtiari K, Daffre S, Deponte K, Wielders SJ, Marquart JA, Hovius JW, van der Poll T, Fikrig E, Bunce MW, Camire RM, Nicolaes GA, Meijers JC, van 't Veer C. Schuijt TJ, et al. Among authors: wielders sj. Circulation. 2013 Jul 16;128(3):254-66. doi: 10.1161/CIRCULATIONAHA.113.003191. Epub 2013 Jul 1. Circulation. 2013. PMID: 23817575 Free PMC article.

2

Rational design of small molecules targeting the C2 domain of coagulation factor VIII.

Nicolaes GA, Kulharia M, Voorberg J, Kaijen PH, Wroblewska A, Wielders S, Schrijver R, Sperandio O, Villoutreix BO. Nicolaes GA, et al. Blood. 2014 Jan 2;123(1):113-20. doi: 10.1182/blood-2013-05-503227. Epub 2013 Nov 13. Blood. 2014. PMID: 24227818 Free article.

3

Identification of novel small molecule inhibitors of activated protein C.

Sperandio O, Wildhagen KC, Schrijver R, Wielders S, Villoutreix BO, Nicolaes GA. Sperandio O, et al. Thromb Res. 2014 Jun;133(6):1105-14. doi: 10.1016/j.thromres.2014.01.026. Epub 2014 Jan 25. Thromb Res. 2014. PMID: 24513148

4

The C-terminus of tissue factor pathway inhibitor-α inhibits factor V activation by protecting the Arg¹⁵⁴⁵ cleavage site.

van Doorn P, Rosing J, Wielders SJ, Hackeng TM, Castoldi E. van Doorn P, et al. Among authors: wielders sj. J Thromb Haemost. 2017 Jan;15(1):140-149. doi: 10.1111/jth.13559. Epub 2016 Dec 3. J Thromb Haemost. 2017. PMID: 27801970 Free article.

5

Factor Xa-driven thrombin generation in plasma: dependency on the aminophospholipid density of membranes and inhibition by phospholipid-binding proteins.

Wielders SJ, Ungethüm L, Reutelingsperger CP, Bevers EM, Lindhout T. Wielders SJ, et al. Thromb Haemost. 2007 Nov;98(5):1056-62. Thromb Haemost. 2007. PMID: 18000611

6

Factor XI-dependent reciprocal thrombin generation consolidates blood coagulation when tissue factor is not available.

Wielders SJ, Béguin S, Hemker HC, Lindhout T. Wielders SJ, et al. Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1138-42. doi: 10.1161/01.ATV.0000128125.80559.9c. Epub 2004 Apr 8. Arterioscler Thromb Vasc Biol. 2004. PMID: 15072993

7

Anticoagulant and antithrombotic properties of intracellular protease-activated receptor antagonists.

Wielders SJ, Bennaghmouch A, Reutelingsperger CP, Bevers EM, Lindhout T. Wielders SJ, et al. J Thromb Haemost. 2007 Mar;5(3):571-6. doi: 10.1111/j.1538-7836.2007.02364.x. Epub 2006 Dec 13. J Thromb Haemost. 2007. PMID: 17166251 Free article.

8

von Willebrand factor stimulates thrombin-induced exposure of procoagulant phospholipids on the surface of fibrin-adherent platelets.

Briedé JJ, Wielders SJ, Heemskerk JW, Baruch D, Hemker HC, Lindhout T. Briedé JJ, et al. Among authors: wielders sj. J Thromb Haemost. 2003 Mar;1(3):559-65. doi: 10.1046/j.1538-7836.2003.00077.x. J Thromb Haemost. 2003. PMID: 12871466 Free article.

9

Design and synthesis of thrombin substrates with modified kinetic parameters.

Rijkers DT, Wielders SJ, Tesser GI, Hemker HC. Rijkers DT, et al. Among authors: wielders sj. Thromb Res. 1995 Sep 15;79(5-6):491-9. doi: 10.1016/0049-3848(95)00139-i. Thromb Res. 1995. PMID: 7502275

10

Reversible inhibition of the platelet procoagulant response through manipulation of the Gardos channel.

Wolfs JL, Wielders SJ, Comfurius P, Lindhout T, Giddings JC, Zwaal RF, Bevers EM. Wolfs JL, et al. Among authors: wielders sj. Blood. 2006 Oct 1;108(7):2223-8. doi: 10.1182/blood-2006-01-009613. Epub 2006 Jun 1. Blood. 2006. PMID: 16741254 Free article.

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