Heimbach T - Search Results

1

A simplified PBPK modeling approach for prediction of pharmacokinetics of four primarily renally excreted and CYP3A metabolized compounds during pregnancy.

Xia B, Heimbach T, Gollen R, Nanavati C, He H. Xia B, et al. Among authors: heimbach t. AAPS J. 2013 Oct;15(4):1012-24. doi: 10.1208/s12248-013-9505-3. Epub 2013 Jul 9. AAPS J. 2013. PMID: 23835676 Free PMC article.

2

Practical anticipation of human efficacious doses and pharmacokinetics using in vitro and preclinical in vivo data.

Heimbach T, Lakshminarayana SB, Hu W, He H. Heimbach T, et al. AAPS J. 2009 Sep;11(3):602-14. doi: 10.1208/s12248-009-9136-x. Epub 2009 Aug 26. AAPS J. 2009. PMID: 19707878 Free PMC article.

3

Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions.

Xia B, Heimbach T, Lin TH, He H, Wang Y, Tan E. Xia B, et al. Among authors: heimbach t. Cancer Chemother Pharmacol. 2012 Jun;69(6):1567-82. doi: 10.1007/s00280-012-1863-5. Epub 2012 Apr 11. Cancer Chemother Pharmacol. 2012. PMID: 22526410

4

Nilotinib preclinical pharmacokinetics and practical application toward clinical projections of oral absorption and systemic availability.

Xia B, Heimbach T, He H, Lin TH. Xia B, et al. Among authors: heimbach t. Biopharm Drug Dispos. 2012 Dec;33(9):536-49. doi: 10.1002/bdd.1821. Epub 2012 Nov 19. Biopharm Drug Dispos. 2012. PMID: 23097199

5

Case studies for practical food effect assessments across BCS/BDDCS class compounds using in silico, in vitro, and preclinical in vivo data.

Heimbach T, Xia B, Lin TH, He H. Heimbach T, et al. AAPS J. 2013 Jan;15(1):143-58. doi: 10.1208/s12248-012-9419-5. Epub 2012 Nov 10. AAPS J. 2013. PMID: 23139017 Free PMC article.

6

Utility of physiologically based modeling and preclinical in vitro/in vivo data to mitigate positive food effect in a BCS class 2 compound.

Xia B, Heimbach T, Lin TH, Li S, Zhang H, Sheng J, He H. Xia B, et al. Among authors: heimbach t. AAPS PharmSciTech. 2013 Sep;14(3):1255-66. doi: 10.1208/s12249-013-0018-2. Epub 2013 Aug 17. AAPS PharmSciTech. 2013. PMID: 23955148 Free PMC article. Clinical Trial.

7

Application of physiologically based absorption modeling to formulation development of a low solubility, low permeability weak base: mechanistic investigation of food effect.

Zhang H, Xia B, Sheng J, Heimbach T, Lin TH, He H, Wang Y, Novick S, Comfort A. Zhang H, et al. Among authors: heimbach t. AAPS PharmSciTech. 2014 Apr;15(2):400-6. doi: 10.1208/s12249-014-0075-1. Epub 2014 Jan 17. AAPS PharmSciTech. 2014. PMID: 24435225 Free PMC article.

8

Physiologically based pharmacokinetic modeling for assessing the clinical drug-drug interaction of alisporivir.

Xia B, Barve A, Heimbach T, Zhang T, Gu H, Wang L, Einolf H, Alexander N, Hanna I, Ke J, Mangold JB, He H, Sunkara G. Xia B, et al. Among authors: heimbach t. Eur J Pharm Sci. 2014 Oct 15;63:103-12. doi: 10.1016/j.ejps.2014.06.021. Epub 2014 Jul 4. Eur J Pharm Sci. 2014. PMID: 25008118

9

Prospective Predictions of Human Pharmacokinetics for Eighteen Compounds.

Zhang T, Heimbach T, Lin W, Zhang J, He H. Zhang T, et al. Among authors: heimbach t. J Pharm Sci. 2015 Sep;104(9):2795-806. doi: 10.1002/jps.24373. Epub 2015 Feb 17. J Pharm Sci. 2015. PMID: 25690565

10

Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling.

Zhang J, Heimbach T, Scheer N, Barve A, Li W, Lin W, He H. Zhang J, et al. Among authors: heimbach t. J Pharm Sci. 2016 Apr;105(4):1398-404. doi: 10.1016/j.xphs.2016.01.021. J Pharm Sci. 2016. PMID: 27019957

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