Quadri LE - Search Results

1

Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice.

Lun S, Guo H, Adamson J, Cisar JS, Davis TD, Chavadi SS, Warren JD, Quadri LE, Tan DS, Bishai WR. Lun S, et al. Among authors: quadri le. Antimicrob Agents Chemother. 2013 Oct;57(10):5138-40. doi: 10.1128/AAC.00918-13. Epub 2013 Jul 15. Antimicrob Agents Chemother. 2013. PMID: 23856770 Free PMC article.

2

Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents.

Bythrow GV, Mohandas P, Guney T, Standke LC, Germain GA, Lu X, Ji C, Levendosky K, Chavadi SS, Tan DS, Quadri LEN. Bythrow GV, et al. Among authors: quadri len. Biochemistry. 2019 Feb 12;58(6):833-847. doi: 10.1021/acs.biochem.8b01153. Epub 2019 Jan 10. Biochemistry. 2019. PMID: 30582694 Free PMC article.

3

Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis.

Ferreras JA, Ryu JS, Di Lello F, Tan DS, Quadri LE. Ferreras JA, et al. Among authors: quadri le. Nat Chem Biol. 2005 Jun;1(1):29-32. doi: 10.1038/nchembio706. Epub 2005 May 24. Nat Chem Biol. 2005. PMID: 16407990

4

Mutational and phylogenetic analyses of the mycobacterial mbt gene cluster.

Chavadi SS, Stirrett KL, Edupuganti UR, Vergnolle O, Sadhanandan G, Marchiano E, Martin C, Qiu WG, Soll CE, Quadri LE. Chavadi SS, et al. Among authors: quadri le. J Bacteriol. 2011 Nov;193(21):5905-13. doi: 10.1128/JB.05811-11. Epub 2011 Aug 26. J Bacteriol. 2011. PMID: 21873494 Free PMC article.

5

Cooperation between a coenzyme A-independent stand-alone initiation module and an iterative type I polyketide synthase during synthesis of mycobacterial phenolic glycolipids.

He W, Soll CE, Chavadi SS, Zhang G, Warren JD, Quadri LE. He W, et al. Among authors: quadri le. J Am Chem Soc. 2009 Nov 25;131(46):16744-50. doi: 10.1021/ja904792q. J Am Chem Soc. 2009. PMID: 19799378 Free PMC article.

6

Biosynthesis of cell envelope-associated phenolic glycolipids in Mycobacterium marinum.

Vergnolle O, Chavadi SS, Edupuganti UR, Mohandas P, Chan C, Zeng J, Kopylov M, Angelo NG, Warren JD, Soll CE, Quadri LE. Vergnolle O, et al. Among authors: quadri le. J Bacteriol. 2015 Mar;197(6):1040-50. doi: 10.1128/JB.02546-14. Epub 2015 Jan 5. J Bacteriol. 2015. PMID: 25561717 Free PMC article.

7

Design, synthesis, and biological evaluation of α-hydroxyacyl-AMS inhibitors of amino acid adenylation enzymes.

Davis TD, Mohandas P, Chiriac MI, Bythrow GV, Quadri LE, Tan DS. Davis TD, et al. Among authors: quadri le. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5340-5345. doi: 10.1016/j.bmcl.2016.09.027. Epub 2016 Sep 16. Bioorg Med Chem Lett. 2016. PMID: 27692545 Free PMC article.

8

Inactivation of tesA reduces cell wall lipid production and increases drug susceptibility in mycobacteria.

Chavadi SS, Edupuganti UR, Vergnolle O, Fatima I, Singh SM, Soll CE, Quadri LE. Chavadi SS, et al. Among authors: quadri le. J Biol Chem. 2011 Jul 15;286(28):24616-25. doi: 10.1074/jbc.M111.247601. Epub 2011 May 18. J Biol Chem. 2011. PMID: 21592957 Free PMC article.

9

Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation.

Ferreras JA, Stirrett KL, Lu X, Ryu JS, Soll CE, Tan DS, Quadri LE. Ferreras JA, et al. Among authors: quadri le. Chem Biol. 2008 Jan;15(1):51-61. doi: 10.1016/j.chembiol.2007.11.010. Epub 2007 Dec 27. Chem Biol. 2008. PMID: 18158259 Free PMC article.

10

Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules.

Cisar JS, Ferreras JA, Soni RK, Quadri LE, Tan DS. Cisar JS, et al. Among authors: quadri le. J Am Chem Soc. 2007 Jun 27;129(25):7752-3. doi: 10.1021/ja0721521. Epub 2007 Jun 2. J Am Chem Soc. 2007. PMID: 17542590 Free PMC article.

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