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In vivo evidence that furin from hepatocytes inactivates PCSK9.
Essalmani R, Susan-Resiga D, Chamberland A, Abifadel M, Creemers JW, Boileau C, Seidah NG, Prat A. Essalmani R, et al. Among authors: creemers jw. J Biol Chem. 2011 Feb 11;286(6):4257-63. doi: 10.1074/jbc.M110.192104. Epub 2010 Dec 8. J Biol Chem. 2011. PMID: 21147780 Free PMC article.
Proprotein convertase furin regulates osteocalcin and bone endocrine function.
Al Rifai O, Chow J, Lacombe J, Julien C, Faubert D, Susan-Resiga D, Essalmani R, Creemers JW, Seidah NG, Ferron M. Al Rifai O, et al. Among authors: creemers jw. J Clin Invest. 2017 Nov 1;127(11):4104-4117. doi: 10.1172/JCI93437. Epub 2017 Oct 3. J Clin Invest. 2017. PMID: 28972540 Free PMC article.
The paired basic amino acid-cleaving enzyme 4 (PACE4) is involved in the maturation of insulin receptor isoform B: an opportunity to reduce the specific insulin receptor-dependent effects of insulin-like growth factor 2 (IGF2).
Kara I, Poggi M, Bonardo B, Govers R, Landrier JF, Tian S, Leibiger I, Day R, Creemers JW, Peiretti F. Kara I, et al. Among authors: creemers jw. J Biol Chem. 2015 Jan 30;290(5):2812-21. doi: 10.1074/jbc.M114.592543. Epub 2014 Dec 19. J Biol Chem. 2015. PMID: 25527501 Free PMC article.
148 results