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HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization.
Sivakumaran V, Stanley BA, Tocchetti CG, Ballin JD, Caceres V, Zhou L, Keceli G, Rainer PP, Lee DI, Huke S, Ziolo MT, Kranias EG, Toscano JP, Wilson GM, O'Rourke B, Kass DA, Mahaney JE, Paolocci N. Sivakumaran V, et al. Among authors: huke s. Antioxid Redox Signal. 2013 Oct 10;19(11):1185-97. doi: 10.1089/ars.2012.5057. Antioxid Redox Signal. 2013. PMID: 23919584 Free PMC article.
Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling.
Tocchetti CG, Wang W, Froehlich JP, Huke S, Aon MA, Wilson GM, Di Benedetto G, O'Rourke B, Gao WD, Wink DA, Toscano JP, Zaccolo M, Bers DM, Valdivia HH, Cheng H, Kass DA, Paolocci N. Tocchetti CG, et al. Among authors: huke s. Circ Res. 2007 Jan 5;100(1):96-104. doi: 10.1161/01.RES.0000253904.53601.c9. Epub 2006 Nov 30. Circ Res. 2007. PMID: 17138943 Free PMC article.
Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation.
Feng N, Huke S, Zhu G, Tocchetti CG, Shi S, Aiba T, Kaludercic N, Hoover DB, Beck SE, Mankowski JL, Tomaselli GF, Bers DM, Kass DA, Paolocci N. Feng N, et al. Among authors: huke s. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1880-5. doi: 10.1073/pnas.1417949112. Epub 2015 Jan 12. Proc Natl Acad Sci U S A. 2015. PMID: 25583515 Free PMC article.
Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias.
Chopra N, Yang T, Asghari P, Moore ED, Huke S, Akin B, Cattolica RA, Perez CF, Hlaing T, Knollmann-Ritschel BE, Jones LR, Pessah IN, Allen PD, Franzini-Armstrong C, Knollmann BC. Chopra N, et al. Among authors: huke s. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7636-41. doi: 10.1073/pnas.0902919106. Epub 2009 Apr 21. Proc Natl Acad Sci U S A. 2009. PMID: 19383796 Free PMC article.
Targets for therapy in sarcomeric cardiomyopathies.
Tardiff JC, Carrier L, Bers DM, Poggesi C, Ferrantini C, Coppini R, Maier LS, Ashrafian H, Huke S, van der Velden J. Tardiff JC, et al. Among authors: huke s. Cardiovasc Res. 2015 Apr 1;105(4):457-70. doi: 10.1093/cvr/cvv023. Epub 2015 Jan 29. Cardiovasc Res. 2015. PMID: 25634554 Free PMC article. Review.
39 results