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HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization.
Sivakumaran V, Stanley BA, Tocchetti CG, Ballin JD, Caceres V, Zhou L, Keceli G, Rainer PP, Lee DI, Huke S, Ziolo MT, Kranias EG, Toscano JP, Wilson GM, O'Rourke B, Kass DA, Mahaney JE, Paolocci N. Sivakumaran V, et al. Antioxid Redox Signal. 2013 Oct 10;19(11):1185-97. doi: 10.1089/ars.2012.5057. Antioxid Redox Signal. 2013. PMID: 23919584 Free PMC article.
Playing with cardiac "redox switches": the "HNO way" to modulate cardiac function.
Tocchetti CG, Stanley BA, Murray CI, Sivakumaran V, Donzelli S, Mancardi D, Pagliaro P, Gao WD, van Eyk J, Kass DA, Wink DA, Paolocci N. Tocchetti CG, et al. Among authors: sivakumaran v. Antioxid Redox Signal. 2011 May 1;14(9):1687-98. doi: 10.1089/ars.2010.3859. Epub 2011 Mar 3. Antioxid Redox Signal. 2011. PMID: 21235349 Free PMC article. Review.
Nitric oxide synthases in heart failure.
Carnicer R, Crabtree MJ, Sivakumaran V, Casadei B, Kass DA. Carnicer R, et al. Among authors: sivakumaran v. Antioxid Redox Signal. 2013 Mar 20;18(9):1078-99. doi: 10.1089/ars.2012.4824. Epub 2012 Sep 20. Antioxid Redox Signal. 2013. PMID: 22871241 Free PMC article. Review.
ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity.
Belmonte F, Das S, Sysa-Shah P, Sivakumaran V, Stanley B, Guo X, Paolocci N, Aon MA, Nagane M, Kuppusamy P, Steenbergen C, Gabrielson K. Belmonte F, et al. Among authors: sivakumaran v. Am J Physiol Heart Circ Physiol. 2015 Oct;309(8):H1271-80. doi: 10.1152/ajpheart.00517.2014. Epub 2015 Aug 7. Am J Physiol Heart Circ Physiol. 2015. PMID: 26254336 Free PMC article.
Sunitinib causes dose-dependent negative functional effects on myocardium and cardiomyocytes.
Rainer PP, Doleschal B, Kirk JA, Sivakumaran V, Saad Z, Groschner K, Maechler H, Hoefler G, Bauernhofer T, Samonigg H, Hutterer G, Kass DA, Pieske B, von Lewinski D, Pichler M. Rainer PP, et al. Among authors: sivakumaran v. BJU Int. 2012 Nov;110(10):1455-62. doi: 10.1111/j.1464-410X.2012.11134.x. Epub 2012 Apr 17. BJU Int. 2012. PMID: 22508007
Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts.
Kaludercic N, Carpi A, Nagayama T, Sivakumaran V, Zhu G, Lai EW, Bedja D, De Mario A, Chen K, Gabrielson KL, Lindsey ML, Pacak K, Takimoto E, Shih JC, Kass DA, Di Lisa F, Paolocci N. Kaludercic N, et al. Among authors: sivakumaran v. Antioxid Redox Signal. 2014 Jan 10;20(2):267-80. doi: 10.1089/ars.2012.4616. Epub 2013 May 22. Antioxid Redox Signal. 2014. PMID: 23581564 Free PMC article.
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